{"id":"W2026326610","doi":"10.1007/s00401-014-1296-9","title":"Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease","year":2014,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute on Aging; Newcastle upon Tyne Hospitals NHS Foundation Trust; Medical Research Council; Dunhill Medical Trust; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Alzheimer Society; National Institutes of Health; Newcastle University","keywords":"Neuropathology; Entorhinal cortex; Hippocampus; Dementia; Pathogenesis; Alzheimer's disease; Amyloid (mycology); Neuroscience; Pathology; Medicine; Psychology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039806,0.0002839747,0.0005095331,0.00009358334,0.0001302188,0.00002143428,0.0001087323,0.000101613,0.0001554918],"category_scores_gemma":[0.000473127,0.0001938134,0.0000986868,0.0003257654,0.0003783741,0.00009800376,0.0001040927,0.0002486905,0.00002464992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002091954,"about_ca_system_score_gemma":0.0001113976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001864147,"about_ca_topic_score_gemma":9.893974e-7,"domain_scores_codex":[0.9980789,0.0002499625,0.0002688484,0.0005299178,0.0004361619,0.0004361481],"domain_scores_gemma":[0.9983565,0.0001345121,0.0001640145,0.0004783277,0.0002064428,0.0006601614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005075698,0.003584806,0.9579257,0.00009798086,0.005351618,0.006324571,0.0002773156,0.000003288993,0.01193215,0.00005529375,0.001614034,0.00775753],"study_design_scores_gemma":[0.002521635,0.001608645,0.9903395,0.0000866053,0.001407646,0.0001023368,0.0000136727,0.0004239736,0.003019274,0.00009189347,0.0001800702,0.0002047307],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959131,0.00169064,0.000003164824,0.0007150118,0.00002323501,0.0005285254,0.0001157846,0.0001488785,0.0008616218],"genre_scores_gemma":[0.998683,0.0002593448,0.00007945183,0.0007413848,0.0000177963,0.00002487299,0.0001072448,0.00003983064,0.00004708413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0324138,"threshold_uncertainty_score":0.7903479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02458084477726084,"score_gpt":0.2683801006632219,"score_spread":0.2437992558859611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}