{"id":"W2026339308","doi":"10.1371/journal.pgen.1003627","title":"The BTB-zinc Finger Transcription Factor Abrupt Acts as an Epithelial Oncogene in Drosophila melanogaster through Maintaining a Progenitor-like Cell State","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Health and Medical Research Council; National Cancer Institute; Medical Research Council; National Institutes of Health","keywords":"Biology; Cell biology; Cell fate determination; Transcription factor; Progenitor cell; Drosophila melanogaster; Imaginal disc; Zinc finger; Regulator; Hippo signaling pathway; Cell migration; Cell; Cancer research; Signal transduction; Genetics; Stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001778283,0.0003166319,0.0002117455,0.00004183529,0.0002183635,0.0001401859,0.0003696514,0.0002449208,0.00004859757],"category_scores_gemma":[0.00003013996,0.000255864,0.0001126073,0.000102978,0.0001113627,0.00001629073,0.00007502583,0.0002283515,0.0001286307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003549472,"about_ca_system_score_gemma":0.0001563738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004059323,"about_ca_topic_score_gemma":0.0001150173,"domain_scores_codex":[0.9979417,0.0002126866,0.0004085585,0.0005262504,0.0003010174,0.0006097629],"domain_scores_gemma":[0.9990082,0.00002875335,0.0001264546,0.0005245566,0.0001440029,0.0001680789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008400378,0.0001769872,0.0006496705,0.00001728756,0.00004329428,0.000008236482,0.001547506,0.0001947687,0.9955029,0.000006889687,0.00002362398,0.001744824],"study_design_scores_gemma":[0.0008103569,0.0008134139,0.0003560975,0.0000252285,0.00002760433,0.000009849589,0.0002751527,0.0008840365,0.9850178,0.0005760106,0.01085136,0.0003530738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973614,0.0009302471,0.0001645828,0.0001666455,0.0002701601,0.0006047621,0.00006038912,0.00002928427,0.0004125467],"genre_scores_gemma":[0.9970334,0.0004534009,0.0008970955,0.0003863578,0.0004582337,0.0001178643,0.0001006998,0.00007607719,0.0004769079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01082774,"threshold_uncertainty_score":0.9999893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010216190558928,"score_gpt":0.2460483145544106,"score_spread":0.2259461526488214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}