{"id":"W2026362317","doi":"10.1021/ml200202y","title":"Toward Overcoming <i>Staphylococcus aureus</i> Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue","year":2011,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Achaogen","keywords":"Neomycin; Aminoglycoside; Staphylococcus aureus; Microbiology; Staphylococcal infections; Antibiotics; Staphylococcus; Medicine; Chemistry; Biology; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143072,0.0002743618,0.0002251326,0.00007747255,0.00008357458,0.0002341691,0.0002690253,0.0002518422,0.0004620807],"category_scores_gemma":[0.0001129265,0.0001040062,0.0001466926,0.00008138549,0.0001879142,0.0001400575,0.0001425433,0.0003758655,0.0002757622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263566,"about_ca_system_score_gemma":0.0001572997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001911757,"about_ca_topic_score_gemma":0.000342449,"domain_scores_codex":[0.9999288,0.00001752126,0.00000618659,0.00001788865,0.00001229203,0.00001728042],"domain_scores_gemma":[0.9999378,0.000009411904,0.00002024236,0.000008817432,0.000008289058,0.00001543631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005361444,0.00002236253,0.00005335401,0.0000297261,0.000002057874,0.00004801116,0.00001606054,0.0001895553,0.9979295,0.0001652601,0.00002512128,0.001465378],"study_design_scores_gemma":[0.0000319899,0.0005771951,0.0004469582,0.000005696415,0.00001063995,0.000287807,0.0000126875,0.0006579946,0.9947199,0.00004130407,0.003201744,0.000005996147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811507,0.00114932,0.01355276,0.0002027554,0.00005193616,0.00009588372,0.0002058246,0.0001061741,0.003484625],"genre_scores_gemma":[0.987171,0.0008290363,0.01047688,0.00009735034,0.00001315292,0.00003714388,0.0001657031,0.00001636936,0.001193291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004620807,"threshold_uncertainty_score":0.001642406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02316045847062005,"score_gpt":0.2221534996520312,"score_spread":0.1989930411814111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}