{"id":"W2026380741","doi":"10.1002/jnr.20592","title":"Adenovirus expressing an NPC1‐GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease","year":2005,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Canadian Institutes of Health Research; Terveyden ja hyvinvoinnin laitos; Fondation pour la Recherche Médicale; National Research Foundation; National Niemann-Pick Disease Foundation","keywords":"NPC1; Green fluorescent protein; Niemann–Pick disease; Biology; Chinese hamster ovary cell; Cell biology; Neurodegeneration; Fusion protein; Niemann–Pick disease, type C; Transfection; Endosome; Adenoviridae; Molecular biology; Genetic enhancement; Gene; Cell culture; Pathology; Recombinant DNA; Medicine; Cholesterol; Genetics; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001856338,0.0002083179,0.0003516614,0.0007172717,0.0005731698,0.0002686595,0.000489709,0.00007841884,0.00004646806],"category_scores_gemma":[0.004893696,0.0001535465,0.00007488762,0.00144427,0.0007800131,0.0008670012,0.0002700273,0.001428135,0.00001094562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002210582,"about_ca_system_score_gemma":0.001333125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001213399,"about_ca_topic_score_gemma":0.00001349193,"domain_scores_codex":[0.9939126,0.0006768673,0.000398127,0.000530122,0.003579204,0.0009031283],"domain_scores_gemma":[0.9963918,0.0004106363,0.0002027044,0.0003352018,0.00128066,0.001378956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003243776,0.001336527,0.07368375,0.00005820538,0.00001222222,0.003432399,0.0002990861,0.0003852448,0.9104047,0.00001353632,0.0007609324,0.006369657],"study_design_scores_gemma":[0.002559524,0.006616436,0.9703687,0.0003147782,0.00004234788,0.00127279,0.0001165155,0.009023266,0.008258353,0.00005118163,0.001156436,0.0002196924],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968294,0.0006051979,0.00004915895,0.00183229,0.0001759141,0.0003437555,0.000005359637,0.00002180426,0.0001371573],"genre_scores_gemma":[0.9981774,0.0003146227,0.0001965417,0.0004529239,0.0003275111,0.0000039435,0.000002984078,0.00004352625,0.0004805133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9021463,"threshold_uncertainty_score":0.6261445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09903169026975357,"score_gpt":0.3849153674667354,"score_spread":0.2858836771969818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}