{"id":"W2026380741","doi":"10.1002/jnr.20592","title":"Adenovirus expressing an NPC1‐GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease","year":2005,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Canadian Institutes of Health Research; Terveyden ja hyvinvoinnin laitos; Fondation pour la Recherche Médicale; National Research Foundation; National Niemann-Pick Disease Foundation","keywords":"NPC1; Green fluorescent protein; Niemann–Pick disease; Biology; Chinese hamster ovary cell; Cell biology; Neurodegeneration; Fusion protein; Niemann–Pick disease, type C; Transfection; Endosome; Adenoviridae; Molecular biology; Genetic enhancement; Gene; Cell culture; Pathology; Recombinant DNA; Medicine; Cholesterol; Genetics; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002536754,0.0003649289,0.0002717449,0.0003101536,0.0002099073,0.0002893062,0.000270442,0.000362507,0.001408858],"category_scores_gemma":[0.0002432695,0.0001809461,0.0001913963,0.0001658035,0.0003559369,0.000264921,0.0001976308,0.0005825107,0.0004260781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000397897,"about_ca_system_score_gemma":0.0005201158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043424,"about_ca_topic_score_gemma":0.001176092,"domain_scores_codex":[0.9998736,0.00001682253,0.00002192312,0.00002260002,0.00003605416,0.00002894796],"domain_scores_gemma":[0.9997839,0.00003841922,0.00004970659,0.0000426757,0.00002599138,0.00005928948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001688622,0.0000666465,0.0002273436,0.00009275504,0.000009385579,0.0001857313,0.00002810227,0.00017212,0.994023,0.001020628,0.000152,0.003853534],"study_design_scores_gemma":[0.0001205815,0.0004392691,0.002331536,0.00002075199,0.00005637167,0.001434518,0.00005856017,0.002536116,0.9799767,0.0002512161,0.01276262,0.00001177836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803299,0.001600305,0.01363257,0.0002177189,0.0001444581,0.00008673577,0.0006130717,0.0003034461,0.003071955],"genre_scores_gemma":[0.9701223,0.002285369,0.01727112,0.00005056077,0.00002590512,0.00006775193,0.001396107,0.00006918606,0.008711591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001408858,"threshold_uncertainty_score":0.004713058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09903169026975357,"score_gpt":0.3849153674667354,"score_spread":0.2858836771969818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}