{"id":"W2026388727","doi":"10.1016/j.tiv.2006.10.013","title":"Toxic effects of zearalenone and α-zearalenol on the regulation of steroidogenesis and testosterone production in mouse Leydig cells","year":2006,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"China Agricultural University","keywords":"Cholesterol side-chain cleavage enzyme; Leydig cell; Steroidogenic acute regulatory protein; Internal medicine; Zearalenone; Testosterone (patch); Biology; Endocrinology; Percoll; Reproductive toxicity; Chemistry; Toxicity; Metabolism; Mycotoxin; Luteinizing hormone; Biochemistry; Cytochrome P450; Gene expression; Hormone; In vitro; Medicine; Gene; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001627591,0.0004480836,0.000299897,0.000369997,0.0002473076,0.0003133334,0.0002313537,0.0003871023,0.001132985],"category_scores_gemma":[0.000148131,0.000327406,0.0003869496,0.0003366929,0.000467672,0.0002415285,0.0002056028,0.0004311851,0.0002346525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004023055,"about_ca_system_score_gemma":0.0003850919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002549087,"about_ca_topic_score_gemma":0.003015314,"domain_scores_codex":[0.9998274,0.00003616471,0.00001913663,0.0000211862,0.00003690428,0.00005909966],"domain_scores_gemma":[0.9997981,0.00007557098,0.00003203106,0.00002773343,0.00002129271,0.00004514365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00114985,0.00003911749,0.0005912139,0.00004045135,0.00001604846,0.0001763979,0.00005127379,0.0002171325,0.9969532,0.0001557366,0.00002452481,0.0005850783],"study_design_scores_gemma":[0.00002672028,0.0004387412,0.003839886,0.000003861076,0.00002104513,0.0001221673,0.00006405479,0.0002245923,0.9947084,0.00007197315,0.0004731878,0.00000552716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965255,0.001495514,0.0005827553,0.00006143285,0.00002623235,0.00001198344,0.0003421483,0.00002427096,0.000930161],"genre_scores_gemma":[0.9953045,0.001313853,0.0003523962,0.00005434596,0.000008444351,0.00001304524,0.0004233675,0.000007453343,0.002522708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002549087,"threshold_uncertainty_score":0.005068541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009280828293716563,"score_gpt":0.1859247465327334,"score_spread":0.1766439182390168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}