{"id":"W2026400984","doi":"10.1006/nbdi.2002.0543","title":"Potential Synergistic Protection of Retinal Ganglion Cells from Axotomy-Induced Apoptosis by Adenoviral Administration of Glial Cell Line-Derived Neurotrophic Factor and X-Chromosome-Linked Inhibitor of Apoptosis","year":2002,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Medical Research Council; Alexander von Humboldt-Stiftung","keywords":"Glial cell line-derived neurotrophic factor; Neurotrophic factors; XIAP; Cell biology; Neuroprotection; Retinal ganglion cell; Biology; Ciliary neurotrophic factor; Axotomy; Inhibitor of apoptosis; Retina; Neuroscience; GDNF family of ligands; Apoptosis; Programmed cell death; Regeneration (biology); Caspase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004318223,0.0006412673,0.0005608425,0.0003672666,0.0003130545,0.0004368421,0.0004464994,0.0005392493,0.001873825],"category_scores_gemma":[0.0003286416,0.0002689186,0.0005944694,0.0002932093,0.0003607222,0.0005188237,0.0003212999,0.00100197,0.0002255094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004296981,"about_ca_system_score_gemma":0.0006972838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007482041,"about_ca_topic_score_gemma":0.001695222,"domain_scores_codex":[0.9997003,0.00005956982,0.00003183639,0.00003737695,0.00004681587,0.0001241005],"domain_scores_gemma":[0.9997376,0.00008658774,0.00004041034,0.0000461918,0.00002071444,0.00006846298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00393095,0.0002161677,0.0003046068,0.0001823828,0.00006070514,0.0002236125,0.00005644307,0.0002469384,0.9890305,0.0006678273,0.0001389775,0.004940829],"study_design_scores_gemma":[0.0004622639,0.003198627,0.004179761,0.00003110891,0.0001451135,0.0006043582,0.00008732251,0.001276389,0.9880455,0.0002199747,0.001736991,0.00001258325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990845,0.004823762,0.001666861,0.0001763623,0.0000995501,0.00006600789,0.000217265,0.00007328879,0.002031835],"genre_scores_gemma":[0.9956604,0.001441889,0.001558269,0.00003414738,0.00002730235,0.00006663377,0.000158228,0.000008713615,0.001044355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873825,"threshold_uncertainty_score":0.006268561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077761953801558,"score_gpt":0.2032137480860302,"score_spread":0.1924361285480146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}