{"id":"W2026417656","doi":"10.3899/jrheum.080576","title":"Metaanalysis of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphisms Affecting Methotrexate Toxicity","year":2009,"lang":"en","type":"review","venue":"The Journal of Rheumatology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health","keywords":"Medicine; Pharmacogenetics; Methylenetetrahydrofolate reductase; Methotrexate; Toxicity; Pharmacology; Rheumatoid arthritis; Internal medicine; Meta-analysis; Oncology; Genotype; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0311523,0.003419565,0.01526762,0.005506615,0.0007304535,0.003205889,0.002676306,0.002434355,0.003018636],"category_scores_gemma":[0.04985404,0.00152199,0.06574508,0.006584221,0.0006081965,0.00132166,0.001606709,0.002212535,0.0003437439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002147569,"about_ca_system_score_gemma":0.002079244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004913219,"about_ca_topic_score_gemma":0.006546992,"domain_scores_codex":[0.9700513,0.02149056,0.003862593,0.002277463,0.001806147,0.0005119132],"domain_scores_gemma":[0.9600034,0.03128567,0.003420256,0.002937129,0.001947617,0.0004058431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002640222,0.00001850782,0.01107915,0.01948639,0.9610659,0.0001444241,0.00002590769,0.001399934,0.0003038349,0.0001066362,0.0004332544,0.003295892],"study_design_scores_gemma":[0.0004279008,0.0002674657,0.007207191,0.001662985,0.9883415,0.0001197588,0.00001950423,0.0006811132,0.0001983947,0.0003524903,0.0007035732,0.00001806522],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04173391,0.9486831,0.004903328,0.0009475545,0.0006699527,0.0003528555,0.001806294,0.0001628263,0.0007402364],"genre_scores_gemma":[0.7705073,0.2156855,0.007308294,0.00135394,0.0007092652,0.001022084,0.002406501,0.0001769151,0.0008302216],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0311523,"threshold_uncertainty_score":0.1647511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04384986043886513,"score_gpt":0.3627850472518429,"score_spread":0.3189351868129777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}