{"id":"W2026420170","doi":"10.1093/protein/gzu018","title":"The intrinsic cysteine and histidine residues of the anti-Salmonella antibody Se155-4: a model for the introduction of new functions into antibody-binding sites","year":2014,"lang":"en","type":"article","venue":"Protein Engineering Design and Selection","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Hapten; Chemistry; Antigen; Binding site; Antibody; Histidine; Biochemistry; Cysteine; Enzyme; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007063962,0.000144195,0.0002274286,0.0001015897,0.0003583865,0.00002819362,0.00008179447,0.00006473174,0.000001915199],"category_scores_gemma":[0.0004478546,0.00007693194,0.00006446602,0.000311578,0.0001168314,0.00006097502,0.00004649669,0.0002035225,4.021874e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002554932,"about_ca_system_score_gemma":0.0000573909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001421543,"about_ca_topic_score_gemma":0.00001316771,"domain_scores_codex":[0.9990718,0.00005611312,0.0002649581,0.0001998626,0.0002102415,0.0001970698],"domain_scores_gemma":[0.9992319,0.0002944196,0.000100663,0.0001523028,0.0001623059,0.00005837174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004091639,0.00002581753,0.001247786,0.0003554276,0.00009379709,1.102895e-7,0.0002337916,0.01231014,0.9781567,0.0014568,0.0003924309,0.005318005],"study_design_scores_gemma":[0.0006099262,0.0005757427,0.00588496,0.0001273899,0.0001110774,0.00004378734,0.00003778382,0.848426,0.1411117,0.0004030711,0.002559663,0.0001088901],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5904431,0.001416415,0.4042,0.002849313,0.00007393512,0.0009816411,0.000002263529,0.00002777346,0.000005571082],"genre_scores_gemma":[0.9916829,0.0004379252,0.005624042,0.000008716082,0.0004399115,0.00004237417,0.00001111929,0.00002091934,0.001732042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.837045,"threshold_uncertainty_score":0.3137194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032657452832006,"score_gpt":0.2716278822369271,"score_spread":0.251301307708607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}