{"id":"W2026422641","doi":"10.4161/mabs.25488","title":"LC-MS characterization and purity assessment of a prototype bispecific antibody","year":2013,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Chemistry; Peptide; Antibody; Immunoglobulin light chain; Chromatography; Mass spectrometry; Bispecific antibody; Biochemistry; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006123243,0.000440499,0.000244462,0.0006451673,0.0003241999,0.000360419,0.0004287431,0.0004837465,0.0006038371],"category_scores_gemma":[0.0005904909,0.0001213437,0.0002139475,0.000331399,0.0001832498,0.0002526211,0.0003175333,0.0004791234,0.0004564175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003330368,"about_ca_system_score_gemma":0.000351086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007024495,"about_ca_topic_score_gemma":0.0007510698,"domain_scores_codex":[0.9993224,0.0000843973,0.00004865711,0.0001567014,0.0003303929,0.00005751072],"domain_scores_gemma":[0.9996724,0.00005166544,0.00005599925,0.00002790447,0.0001530242,0.00003902032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002988502,0.00002868341,0.0006456674,0.00001498449,0.000007023503,0.00002752919,0.00001403912,0.0000617728,0.9968719,0.00004515668,0.00003761528,0.002215874],"study_design_scores_gemma":[0.00000708993,0.000201757,0.006525856,0.000008974947,0.00002192535,0.0003418495,0.00003510351,0.004013698,0.9870604,0.00006587465,0.001708031,0.000009464186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439772,0.001235446,0.05087401,0.0001062551,0.00003354318,0.0001455458,0.0009323566,0.0002681805,0.002427449],"genre_scores_gemma":[0.9100618,0.001193922,0.08165769,0.0003611821,0.00002245489,0.000297801,0.003308099,0.0001066879,0.002990366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007024495,"threshold_uncertainty_score":0.003238261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302194403591305,"score_gpt":0.3469722821506933,"score_spread":0.3239503381147802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}