{"id":"W2026422641","doi":"10.4161/mabs.25488","title":"LC-MS characterization and purity assessment of a prototype bispecific antibody","year":2013,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Chemistry; Peptide; Antibody; Immunoglobulin light chain; Chromatography; Mass spectrometry; Bispecific antibody; Biochemistry; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001057917,0.00007599138,0.0001775253,0.00007170338,0.00004165319,0.00001991459,0.000042739,0.00004363854,0.001079988],"category_scores_gemma":[0.00001618415,0.00005516707,0.00003217653,0.0001091009,0.00007786388,0.0000760948,0.00004986588,0.0001126747,0.00004934821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001310757,"about_ca_system_score_gemma":0.00004435429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002033411,"about_ca_topic_score_gemma":0.000002319229,"domain_scores_codex":[0.9992757,0.00002729966,0.0001661606,0.0001428828,0.0002431535,0.0001447343],"domain_scores_gemma":[0.9995721,0.00002084448,0.00004621396,0.0001300429,0.0001389547,0.00009184415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008687883,0.0001544075,0.348619,0.0003432049,0.00002898351,0.000007959458,0.00006407125,5.154067e-8,0.6350147,0.001482685,0.0001768256,0.01402126],"study_design_scores_gemma":[0.0003476363,0.0003682715,0.9776685,0.00006622076,0.000008585851,0.00001776244,0.00001418522,0.0007967732,0.004061888,0.00009877863,0.01649399,0.000057426],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99274,0.00006453925,0.0002184506,0.002324948,0.0000413255,0.0009059301,0.00001335555,0.0000156694,0.003675825],"genre_scores_gemma":[0.9957227,0.0002247869,0.0005719425,0.00009388813,0.00009250627,0.00006025442,0.0001384782,0.000008454148,0.003087034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6309528,"threshold_uncertainty_score":0.9998332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302194403591305,"score_gpt":0.3469722821506933,"score_spread":0.3239503381147802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}