{"id":"W2026442560","doi":"10.1038/cdd.2010.174","title":"Therapeutic targets in cancer cell metabolism and death","year":2011,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; Genentech","keywords":"Oxidative phosphorylation; Warburg effect; Cancer cell; Glycolysis; Mitochondrion; Cell biology; Biology; Cancer; Cell growth; Population; Programmed cell death; Anabolism; Cancer research; Apoptosis; Metabolism; Biochemistry; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005651733,0.000142535,0.0001451193,0.00003618276,0.00004928982,0.00001892505,0.00005401556,0.0001126619,0.00006531302],"category_scores_gemma":[0.000003331803,0.0001267611,0.0000353394,0.00003007056,0.00001709513,0.000009681839,0.00004169357,0.00005462861,0.000001301477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007281799,"about_ca_system_score_gemma":0.0000273406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004211764,"about_ca_topic_score_gemma":0.0002967872,"domain_scores_codex":[0.9992945,0.00003553319,0.0001330527,0.0002791751,0.00006249263,0.0001952954],"domain_scores_gemma":[0.9996943,0.000003836468,0.00005776605,0.0001320774,0.00002777662,0.00008427696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002083648,0.0002964922,0.07991713,0.0001121764,0.00004862492,9.626486e-7,0.001402644,0.000002732767,0.8917877,0.0008063485,0.0002700181,0.02514681],"study_design_scores_gemma":[0.001593044,0.00007165671,0.677694,0.000007449351,0.000105222,0.00000200872,0.00008972164,0.0001198711,0.3012432,0.000707393,0.01809332,0.0002731403],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9200678,0.07637312,0.0007675618,0.000007536138,0.0004404775,0.0001488909,0.00001297396,0.000007290726,0.002174307],"genre_scores_gemma":[0.9750648,0.02362942,0.0001696053,0.0001532704,0.0002788992,0.00003444753,0.00005561596,0.0000151637,0.000598758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5977769,"threshold_uncertainty_score":0.5169169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908806355246757,"score_gpt":0.2347328038749443,"score_spread":0.2156447403224767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}