{"id":"W2026460297","doi":"10.1177/1087057111408605","title":"Development and Application of a Cellular, Gain-of-Signal, Bioluminescent Reporter Screen for Inhibitors of Type II Secretion in Pseudomonas aeruginosa and Burkholderia pseudomallei","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Institutes of Health; University of Calgary; Harvard University; Colorado State University","keywords":"Bioluminescence; Burkholderia pseudomallei; Pseudomonas aeruginosa; Microbiology; Secretion; Burkholderia; Pseudomonas; Quorum sensing; Biology; Biofilm; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003086213,0.0009169351,0.0007704921,0.0008846123,0.0002261713,0.0006156071,0.0004206386,0.0005674504,0.001101542],"category_scores_gemma":[0.0002655036,0.0003707903,0.0004673603,0.0006732832,0.0002026561,0.0002680458,0.0003753216,0.0005994441,0.0005570366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003607314,"about_ca_system_score_gemma":0.0004030614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008382446,"about_ca_topic_score_gemma":0.002244955,"domain_scores_codex":[0.9996529,0.00005624564,0.00003169531,0.00006395629,0.0001468664,0.00004840537],"domain_scores_gemma":[0.9997935,0.00003831793,0.00004347638,0.00002330568,0.00005580535,0.00004565781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007722004,0.0001109491,0.0001657421,0.00005199648,0.000009679214,0.00006114915,0.000009327719,0.0001832905,0.9964791,0.00003244424,0.00004168999,0.002777448],"study_design_scores_gemma":[0.0001152173,0.003074542,0.003125542,0.00001103379,0.00006859137,0.0004557236,0.00003719974,0.001398957,0.9881522,0.00004042313,0.003504633,0.00001596327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714814,0.003607073,0.01635693,0.0005171775,0.00006203833,0.0009410838,0.002756193,0.0004701003,0.003807894],"genre_scores_gemma":[0.954008,0.004759517,0.02776655,0.0002223467,0.00002246685,0.0005776577,0.004092339,0.00007716042,0.008473866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101542,"threshold_uncertainty_score":0.003685057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809143342213993,"score_gpt":0.2502907686891238,"score_spread":0.2221993352669839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}