{"id":"W2026460297","doi":"10.1177/1087057111408605","title":"Development and Application of a Cellular, Gain-of-Signal, Bioluminescent Reporter Screen for Inhibitors of Type II Secretion in Pseudomonas aeruginosa and Burkholderia pseudomallei","year":2011,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services; National Institutes of Health; University of Calgary; Harvard University; Colorado State University","keywords":"Bioluminescence; Burkholderia pseudomallei; Pseudomonas aeruginosa; Microbiology; Secretion; Burkholderia; Pseudomonas; Quorum sensing; Biology; Biofilm; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002693971,0.000128271,0.0003377507,0.0001983707,0.00003568199,0.000004385268,0.00003055222,0.0001025215,0.00001222114],"category_scores_gemma":[0.0000311746,0.0001137319,0.00005243898,0.0002075371,0.0001192674,0.0001110555,0.00005322553,0.00005035723,2.051158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002534281,"about_ca_system_score_gemma":0.00009936472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003142863,"about_ca_topic_score_gemma":0.00004706792,"domain_scores_codex":[0.998929,0.00001522411,0.0005635944,0.0002400649,0.0001225179,0.0001296537],"domain_scores_gemma":[0.9993161,0.00002301798,0.0002932072,0.0001874174,0.0001280627,0.00005217874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006247532,0.0005579779,0.1138652,0.0006888423,0.00009348352,0.000002992508,0.001637794,0.000001573034,0.8765564,0.001113795,0.00009553208,0.004761699],"study_design_scores_gemma":[0.001998738,0.000706103,0.09122648,0.0004333021,0.0001340673,0.00002327826,0.0005724567,0.0002046613,0.903495,0.0001571359,0.000875884,0.0001728534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914529,0.0002931158,0.007073277,0.00002539546,0.00008374456,0.0007700958,0.00001115194,0.000008800669,0.0002815039],"genre_scores_gemma":[0.9943288,0.00008654364,0.005335622,0.00001245095,0.00003762086,0.00006424819,0.00005697151,0.00001522536,0.00006251538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02693866,"threshold_uncertainty_score":0.4637851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809143342213993,"score_gpt":0.2502907686891238,"score_spread":0.2221993352669839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}