{"id":"W2026481261","doi":"10.1021/ol0527328","title":"Formal Enantioselective Synthesis of (+)-Compactin","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Enantioselective synthesis; Stereocenter; Chemistry; Formal synthesis; Chirality (physics); Aldehyde; Stereochemistry; Sequence (biology); Organocatalysis; Stereoisomerism; Michael reaction; Combinatorial chemistry; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215164,0.0001111556,0.0002465717,0.00008281852,0.00004653101,0.000007620893,0.00006717689,0.00005216542,0.0004414853],"category_scores_gemma":[0.000125407,0.00007999662,0.00008769008,0.0002348858,0.00005868684,0.00008978697,0.00001952746,0.0001131476,0.0000447004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006046527,"about_ca_system_score_gemma":0.00003367181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001437972,"about_ca_topic_score_gemma":0.00001033772,"domain_scores_codex":[0.9992318,0.0000216278,0.0002010414,0.0001732278,0.0001368325,0.000235478],"domain_scores_gemma":[0.9995832,0.00006552447,0.00009163864,0.0001740886,0.00005125831,0.00003429767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000724107,0.00007020774,0.001081715,0.00004768676,0.00004097118,0.000009235708,0.00002473116,3.242589e-7,0.9842684,0.00006003585,0.0124544,0.001869927],"study_design_scores_gemma":[0.0002504963,0.00003686875,0.01994197,0.00005249371,0.00009957035,0.0000573276,0.00001766155,0.000003273188,0.9781619,0.000009516506,0.00127525,0.00009362171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891891,0.00005883146,0.00007394113,0.009483676,0.00008117709,0.0001490448,0.000006392013,0.00003992199,0.0009178471],"genre_scores_gemma":[0.9981521,0.000006892256,0.0005490925,0.0008731539,0.0002573692,4.113431e-7,0.000004765665,0.00001787326,0.00013835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01886026,"threshold_uncertainty_score":0.4833955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005401685499319122,"score_gpt":0.2008979796097147,"score_spread":0.1954962941103956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}