{"id":"W2026481261","doi":"10.1021/ol0527328","title":"Formal Enantioselective Synthesis of (+)-Compactin","year":2006,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada); TransCanada (Canada)","funders":"","keywords":"Enantioselective synthesis; Stereocenter; Chemistry; Formal synthesis; Chirality (physics); Aldehyde; Stereochemistry; Sequence (biology); Organocatalysis; Stereoisomerism; Michael reaction; Combinatorial chemistry; Catalysis; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001797085,0.0005360988,0.0002670662,0.0002394128,0.0002947921,0.0003803146,0.0003349278,0.0002558142,0.002164548],"category_scores_gemma":[0.0001814662,0.0001070135,0.0001572895,0.0002303193,0.0002384319,0.0002974581,0.0004725411,0.0005505962,0.0007675246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003604426,"about_ca_system_score_gemma":0.0003664454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003887044,"about_ca_topic_score_gemma":0.000655275,"domain_scores_codex":[0.9998633,0.00002468621,0.00001270044,0.00002669307,0.00002799588,0.00004453296],"domain_scores_gemma":[0.9999315,0.000009376957,0.00001965749,0.000009220249,0.00000900758,0.00002122356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002395696,0.0002534473,0.0002688901,0.000228211,0.00002833202,0.0008821166,0.0002025895,0.002514,0.9488362,0.0123825,0.001388398,0.03277572],"study_design_scores_gemma":[0.00005686214,0.0005984936,0.0006032399,0.00001618436,0.00002058234,0.0006234079,0.00004019935,0.001375717,0.9709787,0.001046569,0.02461647,0.00002361247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8718728,0.003538986,0.06690965,0.0008527896,0.0005491655,0.0004503157,0.00163014,0.001046808,0.05314942],"genre_scores_gemma":[0.971564,0.001250719,0.02127953,0.00008744329,0.00003739095,0.00005594742,0.0004291782,0.00005813103,0.005237586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164548,"threshold_uncertainty_score":0.00724113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005401685499319122,"score_gpt":0.2008979796097147,"score_spread":0.1954962941103956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}