{"id":"W2026542497","doi":"10.1371/journal.pone.0070428","title":"Telomerase Contributes to Fludarabine Resistance in Primary Human Leukemic Lymphocytes","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; CancerCare Manitoba; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Fludarabine; Telomerase; Ku70; Cancer research; Ku80; Chronic lymphocytic leukemia; Telomere; Medicine; Immunology; Biology; Leukemia; Chemotherapy; DNA damage; Internal medicine; DNA; Genetics; DNA-binding protein; Cyclophosphamide; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442335,0.0002345317,0.0004240484,0.0002157819,0.0002355756,0.0004840433,0.0001226279,0.0002556252,0.003142667],"category_scores_gemma":[0.0001885844,0.0001981169,0.0002498773,0.0001548003,0.0001444925,0.0001078959,0.0001870226,0.0004221463,0.0007109189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291772,"about_ca_system_score_gemma":0.0001695161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008302828,"about_ca_topic_score_gemma":0.001363077,"domain_scores_codex":[0.999873,0.00002840152,0.0000107964,0.0000215485,0.00002492277,0.00004117409],"domain_scores_gemma":[0.9998858,0.00003642786,0.00001670282,0.00002072828,0.00001546716,0.00002486568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003114688,0.00005645957,0.001215624,0.00005590924,0.000009081558,0.0001467773,0.00004745666,0.00008494975,0.9948403,0.00005636011,0.00009071202,0.003084894],"study_design_scores_gemma":[0.0000932605,0.002196978,0.02356261,0.0000184992,0.000060833,0.001411569,0.0000974575,0.0006705896,0.9671708,0.00007453671,0.004635094,0.000007718877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924132,0.004202448,0.00142055,0.00006097833,0.00002239599,0.00004150995,0.0002949142,0.00008266631,0.001461375],"genre_scores_gemma":[0.9960219,0.001345413,0.0004609068,0.00004779981,0.00001350112,0.00004033536,0.0005229712,0.00001134517,0.00153584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003142667,"threshold_uncertainty_score":0.01051325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03339360348799578,"score_gpt":0.2632676012785659,"score_spread":0.2298739977905701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}