{"id":"W2026586519","doi":"10.1016/j.bmc.2011.11.025","title":"Synthesis and biological activities of 2-[(heteroaryl)methyl]imidazolines","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Imidazoline receptor; Antagonist; Stereochemistry; Chemical synthesis; Biological activity; Receptor; Adrenergic receptor; Derivative (finance); Pharmacology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325671,0.0003700926,0.0003024819,0.0002963747,0.0002025612,0.0001942582,0.0004543703,0.000301916,0.001750948],"category_scores_gemma":[0.0002049614,0.0001371652,0.0001755794,0.0002541382,0.0001496535,0.0002675315,0.0001586113,0.0003497207,0.0004935003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000357249,"about_ca_system_score_gemma":0.0002685425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007141836,"about_ca_topic_score_gemma":0.001836459,"domain_scores_codex":[0.9999036,0.00001946899,0.00001219335,0.00001687124,0.00001622483,0.00003166485],"domain_scores_gemma":[0.9999256,0.00001403585,0.000022758,0.000008106919,0.00001348393,0.00001600013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005014666,0.0001228764,0.0001833198,0.0002501132,0.00001439329,0.0002569429,0.00009896438,0.0006844327,0.9807203,0.0009580945,0.0003444238,0.01586466],"study_design_scores_gemma":[0.00009517068,0.001492656,0.001612681,0.00002082023,0.00003429027,0.0002631591,0.00003361809,0.0007611414,0.9875897,0.0001439356,0.007934432,0.00001842444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617378,0.0167326,0.007387589,0.0004104531,0.000165273,0.0001136028,0.0007898452,0.0001727921,0.01248994],"genre_scores_gemma":[0.9836907,0.005915557,0.00399529,0.0001100094,0.00004939208,0.00005399265,0.0006301355,0.00002347703,0.005531474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750948,"threshold_uncertainty_score":0.005857527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08360215432833865,"score_gpt":0.2710841939752691,"score_spread":0.1874820396469305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}