{"id":"W2026588863","doi":"10.1021/np050315y","title":"Lupeol Long-Chain Fatty Acid Esters with Antimalarial Activity from <i>Holarrhena </i><i>f</i><i>loribunda</i>","year":2005,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Agence Universitaire de la Francophonie; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Lupeol; Traditional medicine; Apocynaceae; Chemistry; Fatty acid; Sierra leone; IC50; Fractionation; Plasmodium falciparum; Medicinal plants; Biology; In vitro; Biochemistry; Malaria; Chromatography; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005089199,0.0003855627,0.0004880947,0.00009971771,0.0001657275,0.0001146906,0.0004677252,0.0002143026,0.00001616087],"category_scores_gemma":[0.0004205967,0.0002700176,0.0002148506,0.0002277523,0.0001776892,0.0001199257,0.0001309671,0.0007692198,0.000007849149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000681228,"about_ca_system_score_gemma":0.000222398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000244822,"about_ca_topic_score_gemma":0.00004284732,"domain_scores_codex":[0.9978164,0.0001707795,0.0004376746,0.0005682848,0.0005455982,0.0004612183],"domain_scores_gemma":[0.9981644,0.00003945239,0.0006004405,0.0005409892,0.0004996862,0.0001550852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002485825,0.0001725498,0.001114781,0.00002331527,0.0003054369,0.00004203656,0.00006417415,0.00005860336,0.9671578,0.000004609069,0.00420143,0.02436945],"study_design_scores_gemma":[0.001330752,0.0005847826,0.006157535,0.00005359446,0.0001105084,0.0003491298,0.00003071956,0.00001641892,0.972011,0.00002362944,0.01892506,0.0004068193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832553,0.005934769,0.000556313,0.008497298,0.001370199,0.0002508278,0.00003617541,0.00001578676,0.00008333717],"genre_scores_gemma":[0.9867111,0.0002888903,0.005992694,0.0005786292,0.005989158,0.000002190544,0.00003136632,0.00004536903,0.0003606265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02396264,"threshold_uncertainty_score":0.9999752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006284733256291104,"score_gpt":0.212383895355193,"score_spread":0.2060991620989019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}