{"id":"W2026635055","doi":"10.1016/j.cct.2007.07.008","title":"Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: the CombAT (Combination of Avodart® and Tamsulosin) trial rationale and study design","year":2007,"lang":"en","type":"article","venue":"Contemporary Clinical Trials","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Dutasteride; Medicine; Tamsulosin; Doxazosin; Finasteride; Urology; Combination therapy; 5 Alpha-Reductase Inhibitor; Hyperplasia; Prostate; Lower urinary tract symptoms; Urinary retention; International Prostate Symptom Score; Randomized controlled trial; Prostate-specific antigen; Internal medicine; Cancer; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004138743,0.003041125,0.004900729,0.001121449,0.0009474832,0.001718589,0.001462815,0.002946998,0.006888418],"category_scores_gemma":[0.0035805,0.001277752,0.002303411,0.001496546,0.002975546,0.001627548,0.0008027626,0.00333767,0.001359293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009159287,"about_ca_system_score_gemma":0.00152591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009117546,"about_ca_topic_score_gemma":0.001821728,"domain_scores_codex":[0.9977317,0.001294148,0.000172854,0.0003011851,0.0001773713,0.0003228513],"domain_scores_gemma":[0.998727,0.0004026731,0.0002972588,0.0001095943,0.00007738154,0.000386018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9748129,0.003940839,0.001434497,0.001129439,0.001042218,0.00007796069,0.00008694656,0.0003945545,0.00199095,0.0004840616,0.0005878657,0.01401774],"study_design_scores_gemma":[0.9240106,0.07126243,0.001155956,0.000054617,0.0009571413,0.00004979521,0.00003940741,0.0001637794,0.0003898009,0.0002900091,0.001603214,0.00002323147],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9190857,0.02407684,0.002317445,0.002423872,0.001565507,0.0394489,0.002409187,0.0002576403,0.008414781],"genre_scores_gemma":[0.9219387,0.01202692,0.004929175,0.002575925,0.002077875,0.0480654,0.001568823,0.00006327122,0.006754052],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.006888418,"threshold_uncertainty_score":0.02304405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2520150131980922,"score_gpt":0.4387874173259612,"score_spread":0.1867724041278691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}