{"id":"W2026635055","doi":"10.1016/j.cct.2007.07.008","title":"Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: the CombAT (Combination of Avodart® and Tamsulosin) trial rationale and study design","year":2007,"lang":"en","type":"article","venue":"Contemporary Clinical Trials","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Dutasteride; Medicine; Tamsulosin; Doxazosin; Finasteride; Urology; Combination therapy; 5 Alpha-Reductase Inhibitor; Hyperplasia; Prostate; Lower urinary tract symptoms; Urinary retention; International Prostate Symptom Score; Randomized controlled trial; Prostate-specific antigen; Internal medicine; Cancer; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01612255,0.0002669726,0.001057903,0.0002128891,0.0001648155,0.0001231748,0.00006825613,0.0001037661,0.000007790716],"category_scores_gemma":[0.000977798,0.0001569569,0.00003398105,0.0002851195,0.0003666963,0.0003384278,0.00007199713,0.000313112,5.029131e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002175931,"about_ca_system_score_gemma":0.0002879589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006304537,"about_ca_topic_score_gemma":0.00003473775,"domain_scores_codex":[0.9947848,0.00243149,0.001444886,0.0005542031,0.0005281617,0.0002564994],"domain_scores_gemma":[0.9941225,0.004741797,0.0004123503,0.000243753,0.0002485878,0.0002310333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6150572,0.004510475,0.3500853,0.0002514173,0.0006001535,0.0001565996,0.006673744,0.000009503316,0.0009299714,0.0004469359,0.0004486683,0.02083012],"study_design_scores_gemma":[0.4471782,0.08520757,0.4558837,0.0005371847,0.0002399803,0.0001042671,0.004684498,0.001582027,0.001329331,0.002369236,0.0003986142,0.0004854751],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789786,0.001102534,0.0004905997,0.002837358,0.00003567195,0.01627477,0.00003117516,0.00001713067,0.0002321846],"genre_scores_gemma":[0.998004,0.00065926,0.0004875843,0.0002317323,0.00004513736,0.000261989,0.00004468252,0.00003054366,0.0002351392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.167879,"threshold_uncertainty_score":0.6400515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2520150131980922,"score_gpt":0.4387874173259612,"score_spread":0.1867724041278691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}