{"id":"W2026673361","doi":"10.1158/0008-5472.can-04-3071","title":"BRCA2 Regulates Homologous Recombination in Response to DNA Damage: Implications for Genome Stability and Carcinogenesis","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"RAD51; Homologous recombination; Non-allelic homologous recombination; Gene conversion; Biology; Sister chromatids; Mitotic crossover; Genetics; Direct repeat; FLP-FRT recombination; Homologous chromosome; Non-homologous end joining; BRCA2 Protein; DNA repair; Genome instability; Molecular biology; DNA; DNA damage; Gene; Genetic recombination; Recombination; Genome; Mutation; Chromosome; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001750452,0.00008317889,0.0001012056,0.000145735,0.0001170696,0.0000320584,0.0001950316,0.0001078753,0.00002520774],"category_scores_gemma":[0.0004658617,0.00008919136,0.00002958118,0.0002391437,0.00007957122,0.000005841078,0.0001646252,0.00007956778,0.000003416695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083851,"about_ca_system_score_gemma":0.0002115059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008729825,"about_ca_topic_score_gemma":0.0007470283,"domain_scores_codex":[0.9986869,0.000257596,0.000155536,0.0004584148,0.0001056816,0.0003359447],"domain_scores_gemma":[0.999038,0.0000918267,0.00002152366,0.0004484198,0.0002882391,0.0001119771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005635013,0.00004485886,0.001609005,0.00001863211,0.000007537669,3.205216e-7,0.0001385028,0.00003305521,0.9912942,0.0001174489,0.0001734296,0.005999528],"study_design_scores_gemma":[0.00044665,0.0003195587,0.1531751,0.000006036398,0.000002959172,0.00000247303,0.00008889876,0.00002627471,0.8371611,0.0007576359,0.00790732,0.0001060161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925708,0.0006938991,0.0001397736,0.005550553,0.00002393931,0.000875202,0.00007984631,0.000008800928,0.00005717864],"genre_scores_gemma":[0.9972142,0.0001164846,0.0009485868,0.00009296874,0.00007471002,0.0009992298,0.00003464519,0.00002087259,0.0004982801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1541331,"threshold_uncertainty_score":0.3637118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05336800970772768,"score_gpt":0.3757415792679871,"score_spread":0.3223735695602594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}