{"id":"W2026673361","doi":"10.1158/0008-5472.can-04-3071","title":"BRCA2 Regulates Homologous Recombination in Response to DNA Damage: Implications for Genome Stability and Carcinogenesis","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"RAD51; Homologous recombination; Non-allelic homologous recombination; Gene conversion; Biology; Sister chromatids; Mitotic crossover; Genetics; Direct repeat; FLP-FRT recombination; Homologous chromosome; Non-homologous end joining; BRCA2 Protein; DNA repair; Genome instability; Molecular biology; DNA; DNA damage; Gene; Genetic recombination; Recombination; Genome; Mutation; Chromosome; Germline mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001806561,0.0003825362,0.0003419694,0.0003486641,0.0002015386,0.0005766851,0.0002517735,0.0003335541,0.001482208],"category_scores_gemma":[0.0001237329,0.0001659831,0.000218394,0.0002299441,0.0002560235,0.0003206353,0.0002466073,0.0003104521,0.0003847782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004190583,"about_ca_system_score_gemma":0.000223833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005202516,"about_ca_topic_score_gemma":0.0004998877,"domain_scores_codex":[0.9998757,0.00001928324,0.00000858282,0.0000274884,0.0000334465,0.00003550156],"domain_scores_gemma":[0.9998937,0.000009639363,0.0000253881,0.00001074738,0.00001167212,0.00004889035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001799138,0.00002585687,0.001070071,0.00005096025,0.000007361459,0.0001748066,0.00001940263,0.0001164191,0.9967815,0.0002593559,0.00008281216,0.001231488],"study_design_scores_gemma":[0.00004510569,0.0002382112,0.06544845,0.00001843356,0.00003624196,0.00128574,0.00008026441,0.001778252,0.9224777,0.0003865261,0.008183922,0.00002119688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783086,0.01309121,0.002859053,0.0004576914,0.00005365414,0.00002550148,0.0009249185,0.0001760097,0.004103428],"genre_scores_gemma":[0.9917409,0.002505213,0.0009745349,0.0001058354,0.00002966589,0.00002353031,0.0006149209,0.00002243912,0.003983015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482208,"threshold_uncertainty_score":0.00495851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05336800970772768,"score_gpt":0.3757415792679871,"score_spread":0.3223735695602594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}