{"id":"W2026692052","doi":"10.1016/j.biomaterials.2015.03.027","title":"Novel micropatterns mechanically control fibrotic reactions at the surface of silicone implants","year":2015,"lang":"en","type":"article","venue":"Biomaterials","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Gebert Rüf Stiftung; Canadian Institutes of Health Research; Competence Centre for Materials Science and Technology; Kommission für Technologie und Innovation; École Polytechnique Fédérale de Lausanne","keywords":"Silicone; Materials science; Micropatterning; Extracellular matrix; Implant; Biomedical engineering; Cell adhesion; Surface modification; Adhesion; Nanotechnology; Medicine; Cell biology; Chemistry; Surgery; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003211442,0.0001179365,0.0001658004,0.00001619182,0.00006446007,0.00002478029,0.0001691756,0.0001016517,0.0001305577],"category_scores_gemma":[0.00008846392,0.00008613665,0.00008316274,0.00003915844,0.00003621811,0.000003708291,0.000118505,0.00001087688,0.00005398172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000210403,"about_ca_system_score_gemma":0.00005002334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002304163,"about_ca_topic_score_gemma":0.000077655,"domain_scores_codex":[0.9991467,0.00007128416,0.0003089564,0.0002049644,0.0001016552,0.0001664211],"domain_scores_gemma":[0.9992259,0.00002004174,0.000174069,0.0003855897,0.0001175832,0.00007677933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001324269,0.00006376673,0.00003965375,0.000009327709,0.00006464296,7.906686e-7,0.00001405963,0.00001230552,0.9974777,0.00007491995,0.002086835,0.00002363256],"study_design_scores_gemma":[0.00065498,0.0001751173,0.0001309463,0.00001229958,0.00002931503,0.0001094863,0.00003714567,0.00003508158,0.9781998,0.00002752922,0.02048736,0.0001009394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942833,0.0001413806,0.003691273,0.0002746226,0.0007785424,0.0002295098,0.0004743329,0.00001026623,0.0001167479],"genre_scores_gemma":[0.998516,0.00002761794,0.0001902361,0.0001254958,0.0001345879,0.00001115501,0.0001551646,0.00001821404,0.0008215854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01927784,"threshold_uncertainty_score":0.3512551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02610679120014272,"score_gpt":0.2637455046894378,"score_spread":0.2376387134892951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}