{"id":"W2026711123","doi":"10.1016/j.jmb.2006.01.045","title":"Recapitulation and Design of Protein Binding Peptide Structures and Sequences","year":2006,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; National Institutes of Health; National Cancer Institute; Canadian Institutes of Health Research; Howard Hughes Medical Institute; U.S. Department of Defense","keywords":"Peptide; Protein design; Computational biology; Protein structure; Chemistry; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005483938,0.0005640797,0.0004615185,0.000334517,0.0004408234,0.0008006777,0.00104328,0.0005767813,0.001311828],"category_scores_gemma":[0.0007212001,0.0004671445,0.0005117701,0.0002520557,0.0004017042,0.0003888037,0.000515792,0.001880382,0.001089195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006125161,"about_ca_system_score_gemma":0.0006710539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005268187,"about_ca_topic_score_gemma":0.0008851109,"domain_scores_codex":[0.9996868,0.00007427793,0.00003647011,0.00005861417,0.00008714966,0.00005666979],"domain_scores_gemma":[0.9997175,0.00005018162,0.0000562459,0.00006785631,0.00005429317,0.0000538494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001545023,0.0001096844,0.0001294024,0.00008151068,0.00001665401,0.000112373,0.00004170331,0.005055342,0.9829217,0.002520921,0.0001601766,0.008696011],"study_design_scores_gemma":[0.00003659265,0.0002700955,0.0001184771,0.000008323486,0.00002450495,0.0001797094,0.00001465542,0.006279734,0.9875609,0.0002902373,0.005204898,0.00001178169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8832748,0.001053853,0.1098443,0.0003703169,0.0002154625,0.0004070669,0.0003946357,0.0005632417,0.00387646],"genre_scores_gemma":[0.9141442,0.001219791,0.07797401,0.0003378628,0.00004552586,0.0002299456,0.0008490948,0.0002181345,0.004981359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311828,"threshold_uncertainty_score":0.004444122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008327304687747252,"score_gpt":0.244132967031647,"score_spread":0.2358056623438997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}