{"id":"W2026721392","doi":"10.1038/nchem.1268","title":"Chemoselective synthesis of ketones and ketimines by addition of organometallic reagents to secondary amides","year":2012,"lang":"en","type":"article","venue":"Nature Chemistry","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Reagent; Combinatorial chemistry; Trifluoromethanesulfonate; Electrophile; Context (archaeology); Organic synthesis; Formal synthesis; Electrophilic amination; Total synthesis; Chemical synthesis; Organic chemistry; Amination; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548175,0.0005894307,0.0002795916,0.0002997475,0.0002136962,0.0002714534,0.0003533798,0.0002153603,0.002147262],"category_scores_gemma":[0.000187997,0.0002396919,0.0002535317,0.0001572526,0.0002398807,0.0003919601,0.0003577568,0.000523359,0.0008089588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002753334,"about_ca_system_score_gemma":0.0002911249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000207643,"about_ca_topic_score_gemma":0.0005519944,"domain_scores_codex":[0.9998605,0.00001939242,0.00001980204,0.00002655624,0.00002507601,0.00004864944],"domain_scores_gemma":[0.999896,0.00001664184,0.00002213918,0.00001296095,0.00002138389,0.0000308546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001987067,0.00004796177,0.0001160061,0.000214299,0.00001346858,0.0004018753,0.00008727555,0.0002859683,0.9908537,0.001494579,0.0003060044,0.005980124],"study_design_scores_gemma":[0.00002611748,0.0002471429,0.0004389694,0.000008029339,0.00001125722,0.0002695112,0.00001896483,0.0002105369,0.9931498,0.0001571816,0.005452505,0.00001003515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297603,0.006280123,0.03087238,0.000445307,0.0004908436,0.0002182209,0.000839152,0.0004444483,0.03064916],"genre_scores_gemma":[0.9819044,0.002731392,0.009152633,0.00007232971,0.00004660708,0.00005102259,0.0003145919,0.00004259391,0.00568442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002147262,"threshold_uncertainty_score":0.007183313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003278969659341826,"score_gpt":0.2196896379912395,"score_spread":0.2164106683318976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}