{"id":"W2026730218","doi":"10.1016/j.jalz.2013.05.1682","title":"P4–289: Normal healthy donors possess plasma IgG reactive to a neutralizing epitope for toxic and amyloid‐seeding beta‐amyloid oligomers","year":2013,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Research Manitoba; Amorfix (Canada); University of British Columbia","funders":"","keywords":"Neurotoxicity; Epitope; Chemistry; Antibody; Monoclonal antibody; Molecular biology; Amyloid (mycology); In vivo; Peptide; Oligomer; Amyloid beta; In vitro; Biochemistry; Immunology; Biology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004303763,0.001142731,0.0008083431,0.0004289424,0.0006955973,0.0004603399,0.0004613234,0.001400512,0.01855716],"category_scores_gemma":[0.0007502861,0.0002816407,0.0002810444,0.0002151044,0.0005385869,0.0004516736,0.0004266152,0.001031401,0.005507777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002749583,"about_ca_system_score_gemma":0.0003508944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008056831,"about_ca_topic_score_gemma":0.0003464052,"domain_scores_codex":[0.999571,0.00005308412,0.00003012468,0.0001435522,0.0001205467,0.00008157683],"domain_scores_gemma":[0.9995358,0.0001091233,0.00005666933,0.00007900148,0.00005874375,0.0001606057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01578153,0.01632934,0.05445035,0.0004899966,0.000275488,0.02266948,0.0005921206,0.0002211914,0.8299142,0.001841149,0.009307267,0.04812789],"study_design_scores_gemma":[0.004339447,0.07468469,0.6161961,0.0001876364,0.0004312793,0.0864474,0.0005031253,0.00223135,0.1592698,0.002428356,0.05316142,0.0001193477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847887,0.0007198427,0.00171607,0.0003608149,0.0002423863,0.0004710588,0.0007876223,0.000180186,0.01073323],"genre_scores_gemma":[0.9824042,0.0002893681,0.0007348462,0.0006394612,0.0001706238,0.0003108798,0.001557328,0.00005242176,0.01384079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01855716,"threshold_uncertainty_score":0.06207991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03764002166585458,"score_gpt":0.3199147949235359,"score_spread":0.2822747732576813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}