{"id":"W2026748222","doi":"10.1016/j.devcel.2013.05.018","title":"Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes","year":2013,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"European Research Council; Bundesministerium für Bildung und Forschung; Fondation Schlumberger pour l’Education et la Recherche; Fonds De La Recherche Scientifique - FNRS; Stichting Diabetes Onderzoek Nederland; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Max-Planck-Gesellschaft; Juvenile Diabetes Research Foundation International","keywords":"Biology; PAX4; PDX1; Cell biology; Reprogramming; Neogenesis; Pancreas; Islet; Glucagon; Embryonic stem cell; Transdifferentiation; Mesenchymal stem cell; Regenerative medicine; Endocrinology; Internal medicine; Cell; Insulin; Stem cell; Gene; Gene expression; Homeobox; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002037913,0.0002965662,0.0005201844,0.0001940576,0.00009781963,0.00004855134,0.0001435252,0.0001362649,0.001045845],"category_scores_gemma":[0.00007488888,0.0002625622,0.00009969771,0.0003844894,0.00006260678,0.0001097589,0.0001082124,0.0001677442,0.0009267396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912292,"about_ca_system_score_gemma":0.0001813734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007854479,"about_ca_topic_score_gemma":0.00002309332,"domain_scores_codex":[0.9979159,0.00004004232,0.0006335429,0.0005179124,0.0003831691,0.0005094112],"domain_scores_gemma":[0.9986921,0.00009112323,0.0001631652,0.0003553738,0.0003147625,0.0003834848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004065595,0.0002208547,0.03420406,0.0001882919,0.00007302094,0.000007530887,0.001668537,0.00000315305,0.9475381,0.000002181628,0.013343,0.002710565],"study_design_scores_gemma":[0.001220107,0.0003144968,0.01078421,0.0001923096,0.00004962249,0.000002946196,0.001878832,0.00009344954,0.9815196,0.00001930003,0.003619305,0.0003058157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840503,0.00005467372,0.000007330799,0.0002712039,0.0005060135,0.0007735055,0.000008514309,0.0001314062,0.01419703],"genre_scores_gemma":[0.9739648,0.00001424203,0.01748388,0.002860308,0.00006030612,0.0001263421,0.00007793424,0.00004799845,0.005364197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03398146,"threshold_uncertainty_score":0.9999827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049520857626205,"score_gpt":0.2252323700913066,"score_spread":0.2147371615150445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}