{"id":"W2026748222","doi":"10.1016/j.devcel.2013.05.018","title":"Adult Duct-Lining Cells Can Reprogram into β-like Cells Able to Counter Repeated Cycles of Toxin-Induced Diabetes","year":2013,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"European Research Council; Bundesministerium für Bildung und Forschung; Fondation Schlumberger pour l’Education et la Recherche; Fonds De La Recherche Scientifique - FNRS; Stichting Diabetes Onderzoek Nederland; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Max-Planck-Gesellschaft; Juvenile Diabetes Research Foundation International","keywords":"Biology; PAX4; PDX1; Cell biology; Reprogramming; Neogenesis; Pancreas; Islet; Glucagon; Embryonic stem cell; Transdifferentiation; Mesenchymal stem cell; Regenerative medicine; Endocrinology; Internal medicine; Cell; Insulin; Stem cell; Gene; Gene expression; Homeobox; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121985,0.0002712299,0.0003981884,0.0003521358,0.0001296127,0.0005480471,0.0002089466,0.0003350772,0.002011144],"category_scores_gemma":[0.0003023861,0.0001526172,0.0004270163,0.0002008344,0.0002845182,0.0002661207,0.0003929092,0.001290007,0.0007179056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001664016,"about_ca_system_score_gemma":0.0001516726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001573441,"about_ca_topic_score_gemma":0.0002991419,"domain_scores_codex":[0.9997075,0.00004959228,0.00003617007,0.00005910143,0.00006255299,0.00008490647],"domain_scores_gemma":[0.9995592,0.0001096393,0.00008307984,0.0001086917,0.00003099506,0.0001084419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025885,0.00004737102,0.0005409556,0.00001734187,0.000007196145,0.0001192105,0.00004814798,0.00009995199,0.9960735,0.0001640117,0.00008234397,0.002697296],"study_design_scores_gemma":[0.00003550707,0.0007680284,0.01086839,0.00001496351,0.0000362549,0.0005340626,0.0001467757,0.0009045117,0.9794465,0.0001578198,0.007074205,0.00001288702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920658,0.0009811977,0.003431107,0.0001194385,0.0001252784,0.00005245837,0.000423746,0.0001929653,0.00260806],"genre_scores_gemma":[0.9922186,0.0004560895,0.001780916,0.0001599187,0.00002094173,0.00004002995,0.0005011455,0.00009459583,0.004727867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002011144,"threshold_uncertainty_score":0.006727993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049520857626205,"score_gpt":0.2252323700913066,"score_spread":0.2147371615150445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}