{"id":"W2026761112","doi":"10.1007/s002800050044","title":"N , N -diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE), a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs","year":2000,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Medical Research Council Canada; Research Manitoba; Manitoba Health Research Council; Bristol-Myers Squibb","keywords":"Cytochrome P450; CYP3A4; Chemistry; Isozyme; Microsome; Pharmacology; Glucuronidation; Metabolism; Biochemistry; In vitro; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471584,0.0002201561,0.0003210703,0.0001923593,0.0002130967,0.0001499349,0.0002303665,0.0003975245,0.002081683],"category_scores_gemma":[0.0002085092,0.0001259858,0.0001484013,0.000132084,0.00021129,0.0001932871,0.000164228,0.0005565138,0.0005037224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162862,"about_ca_system_score_gemma":0.0002331219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000312626,"about_ca_topic_score_gemma":0.0008910795,"domain_scores_codex":[0.9998981,0.00003385675,0.000005013952,0.00001475736,0.00001800062,0.00003034182],"domain_scores_gemma":[0.9999142,0.00002575776,0.00001889207,0.000008464316,0.000005149338,0.00002759902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.004659186,0.0006007096,0.001095729,0.000163374,0.00004058355,0.000454348,0.00002015037,0.0001930634,0.9421088,0.0003206309,0.0006330002,0.04971047],"study_design_scores_gemma":[0.003883375,0.0361268,0.02730623,0.00004880445,0.0001242264,0.005238206,0.00006810045,0.00168161,0.9022034,0.0003113413,0.02298397,0.00002392528],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9725527,0.0110528,0.005449777,0.0006112253,0.0001853238,0.0002077513,0.0003242302,0.000145044,0.009471321],"genre_scores_gemma":[0.9884144,0.004036601,0.002527458,0.0002500412,0.00009401233,0.00009397504,0.0004318383,0.00001471137,0.004136947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002081683,"threshold_uncertainty_score":0.006963968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04876826018524658,"score_gpt":0.3629660713286628,"score_spread":0.3141978111434162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}