{"id":"W2026761112","doi":"10.1007/s002800050044","title":"N , N -diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE), a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs","year":2000,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Medical Research Council Canada; Research Manitoba; Manitoba Health Research Council; Bristol-Myers Squibb","keywords":"Cytochrome P450; CYP3A4; Chemistry; Isozyme; Microsome; Pharmacology; Glucuronidation; Metabolism; Biochemistry; In vitro; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001278888,0.0004226736,0.001162403,0.0001546385,0.0002120309,0.00002598021,0.0001110738,0.000360495,0.007597119],"category_scores_gemma":[0.00003675985,0.0003351367,0.0000966111,0.0001637368,0.0006785328,0.0001212318,0.00006639357,0.0006186445,0.00001178443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009379385,"about_ca_system_score_gemma":0.00005673994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000674293,"about_ca_topic_score_gemma":0.0005151014,"domain_scores_codex":[0.9970667,0.0008573866,0.0007528812,0.0007718196,0.00006033881,0.0004909127],"domain_scores_gemma":[0.9985842,0.0007059266,0.0004166449,0.0001557203,0.00004593982,0.0000915578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009592905,0.0003655022,0.007657443,0.0002334006,0.001152586,0.00002276357,0.004745436,0.00001893628,0.763901,0.00002725391,0.0006957385,0.2115871],"study_design_scores_gemma":[0.06391365,0.002920484,0.07843114,0.0004303632,0.001413221,0.0005231975,0.002170739,0.001037713,0.4098193,0.0001694195,0.4372544,0.001916387],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735165,0.0238509,0.00009650943,0.0007321069,0.0004063754,0.0008031748,0.00006701543,0.00004689898,0.0004805576],"genre_scores_gemma":[0.977368,0.01581449,0.0001409856,0.002128827,0.0002285751,0.00018686,0.000023388,0.00005431739,0.004054563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4365586,"threshold_uncertainty_score":0.9999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04876826018524658,"score_gpt":0.3629660713286628,"score_spread":0.3141978111434162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}