{"id":"W2026772402","doi":"10.1016/j.jmb.2004.08.073","title":"Activation of Calpain by Ca2+: Roles of the Large Subunit N-terminal and Domain III–IV Linker Peptides","year":2004,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Ontario Innovation Trust","keywords":"Calpain; Linker; Proteases; Peptide; Chemistry; Cysteine; Peptide sequence; C-terminus; Calpastatin; Biochemistry; Mutant; Protein subunit; Amino acid; Biophysics; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000408509,0.0001006013,0.0001845538,0.00006124373,0.00004396199,0.000004344039,0.0001162979,0.0001944997,0.000007134607],"category_scores_gemma":[0.0001079332,0.000068853,0.0001381209,0.00007792504,0.0001652516,0.000004831099,0.00006053687,0.0001172038,1.617101e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001487821,"about_ca_system_score_gemma":0.00009292967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001246073,"about_ca_topic_score_gemma":0.00001173533,"domain_scores_codex":[0.9991275,0.0001706711,0.0003617612,0.0001157568,0.000106891,0.0001174296],"domain_scores_gemma":[0.9991651,0.00001372527,0.0004521649,0.0001483494,0.000174931,0.00004570084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002033681,0.00008007353,0.001612199,0.00001660365,0.0000705804,0.000001994951,0.00006618705,0.00009799843,0.996184,0.0005862464,0.0001527927,0.0009279427],"study_design_scores_gemma":[0.001673135,0.0005606248,0.002708527,0.00005405008,0.00003254862,0.000126486,0.0001583311,0.00001243587,0.987146,0.001679222,0.005760677,0.00008799876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593227,0.0007842385,0.03915079,0.0005070455,0.00007497324,0.000106468,0.00001267755,0.000001319937,0.00003981913],"genre_scores_gemma":[0.9989104,0.00008051013,0.0006491104,0.0002041601,0.00007196052,0.000001810097,0.00002239028,0.000008946296,0.0000507627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03958768,"threshold_uncertainty_score":0.2807744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003905840094276167,"score_gpt":0.2337207246768763,"score_spread":0.2298148845826001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}