{"id":"W2026775720","doi":"10.1038/sj.gt.3303085","title":"Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells","year":2007,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada; University of Ottawa; Health Canada","funders":"National Institute of Allergy and Infectious Diseases; Health Canada; U.S. Public Health Service; National Cancer Institute; Public Health Agency of Canada; National Institutes of Health; Public Health Agency","keywords":"Immune system; Adenoviridae; Biology; Genetic enhancement; Spleen; Transgene; Viral vector; Immunology; Biodistribution; Virology; Antigen; CD40; Cytotoxic T cell; In vivo; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003606786,0.0008588622,0.0005023537,0.0006520937,0.0002556523,0.0005626485,0.0003409638,0.0008991371,0.00154362],"category_scores_gemma":[0.0002760366,0.0003252528,0.0003903993,0.000296107,0.0007462896,0.0006168319,0.0002100701,0.001381814,0.0005314897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004404782,"about_ca_system_score_gemma":0.0004867688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401463,"about_ca_topic_score_gemma":0.00106532,"domain_scores_codex":[0.9996872,0.00003657542,0.00002371656,0.00008630622,0.00005020715,0.0001160333],"domain_scores_gemma":[0.9995263,0.0001106629,0.0001137571,0.00007298656,0.00005316899,0.000123123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005161588,0.00006090261,0.000101962,0.00001989945,0.000004166855,0.00005328546,0.00002482934,0.00004677334,0.9985044,0.0001093142,0.0000215092,0.0005369117],"study_design_scores_gemma":[0.00002979934,0.0006002168,0.001685141,0.000003494239,0.00002520869,0.0001711236,0.00003009502,0.0004242506,0.9963057,0.00006365618,0.0006532418,0.000008102351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915776,0.001243574,0.004035803,0.0001717749,0.000088879,0.00005582599,0.0007637621,0.0002188237,0.001843927],"genre_scores_gemma":[0.9873431,0.0008220881,0.002908895,0.0001126308,0.00002770235,0.00008996051,0.00076433,0.0001057585,0.007825632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154362,"threshold_uncertainty_score":0.005163908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0167449884023205,"score_gpt":0.2562379177049153,"score_spread":0.2394929293025948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}