{"id":"W2026783122","doi":"10.1016/j.jbior.2012.04.003","title":"Pre-mRNA splicing: Role of epigenetics and implications in disease","year":2012,"lang":"en","type":"review","venue":"Advances in Biological Regulation","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"RNA splicing; Epigenetics; Chromatin; Biology; Epigenomics; Histone code; Chromatin remodeling; Genetics; Histone; Epigenetic regulation of neurogenesis; Alternative splicing; DNA methylation; Exon; Computational biology; Cell biology; Gene; Nucleosome; Gene expression; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002245532,0.0001685735,0.0004098569,0.00009615496,0.00002331866,0.000005850327,0.0001520198,0.0002384277,0.000004843051],"category_scores_gemma":[0.0001877652,0.000125532,0.00008126437,0.0001758142,0.0001230671,0.000008199291,0.0001241669,0.0001199205,0.000001009392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002579143,"about_ca_system_score_gemma":0.00004645214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007027263,"about_ca_topic_score_gemma":0.000032721,"domain_scores_codex":[0.998808,0.000137037,0.0004105819,0.0003309808,0.00007168255,0.0002417491],"domain_scores_gemma":[0.9993564,0.000070613,0.0001738149,0.0002707772,0.00002862924,0.00009972481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002816966,0.00005265649,0.02187235,0.0005600751,0.000006254957,2.546804e-7,0.00000544164,0.00004368163,0.004014625,0.0007140568,6.485349e-7,0.9727018],"study_design_scores_gemma":[0.000204984,0.0001726621,0.1122094,0.001074619,0.00003886111,0.000004100332,0.000008639853,0.00006449191,0.0001986735,0.002866385,0.8828525,0.0003046594],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05446938,0.9447896,0.0001458961,0.000008862547,0.00001791931,0.0004449892,0.00002447677,0.000003366494,0.00009551275],"genre_scores_gemma":[0.118391,0.880793,0.0003157203,0.0000049889,0.00006456101,0.00008718264,0.0002863195,0.00001007681,0.00004718931],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9723971,"threshold_uncertainty_score":0.5119047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03808619292203341,"score_gpt":0.3709733897986076,"score_spread":0.3328871968765741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}