{"id":"W2026790597","doi":"10.1021/jo8025725","title":"A Rapid Approach to the Synthesis of Highly Functionalized Tetrahydroisoquinolines","year":2009,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006611481,0.0001271379,0.0002227231,0.00001127682,0.00007000523,0.000009798301,0.000520865,0.000108941,0.0001436317],"category_scores_gemma":[0.0006304207,0.00005875665,0.0001668449,0.0001315702,0.00007625121,0.00000295854,0.00005892858,0.0001389959,0.000002192916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001319869,"about_ca_system_score_gemma":0.000060976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001459542,"about_ca_topic_score_gemma":3.181435e-7,"domain_scores_codex":[0.9991432,0.00008518148,0.0003186124,0.0001160459,0.0001957211,0.0001412429],"domain_scores_gemma":[0.9991062,0.0001087198,0.0002806447,0.0003083303,0.0001335859,0.00006251266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002899606,0.0001856405,0.00005764489,0.000008785089,0.00007497898,3.824103e-7,0.00001994168,0.00001842771,0.9899368,0.000002780837,0.001724961,0.007679645],"study_design_scores_gemma":[0.000174767,0.0001651876,0.002906762,0.00001518307,0.00007237644,0.0001935928,0.0001070839,0.000005823197,0.9840582,0.00005114311,0.01216363,0.00008624433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928355,0.001393092,0.0008145612,0.002397916,0.00004683494,0.00007196311,0.000007504437,0.000003839435,0.002428786],"genre_scores_gemma":[0.9982536,0.0003753107,0.0002975164,0.00031976,0.0005490906,0.000001484397,0.00000217148,0.000007161238,0.0001939266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01043867,"threshold_uncertainty_score":0.2396027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326608346975128,"score_gpt":0.2159706452609967,"score_spread":0.2027045617912454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}