{"id":"W2026804034","doi":"10.1021/jm9014197","title":"(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Ovariectomized rat; Agonist; Wnt signaling pathway; Pharmacokinetics; In vitro; Pharmacology; Catenin; Lead compound; In vivo; Combinatorial chemistry; Biochemistry; Receptor; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033666,0.0002293385,0.0001765333,0.0001312405,0.00007825701,0.0001122438,0.0001626601,0.0001617489,0.00116438],"category_scores_gemma":[0.00007145144,0.0001122259,0.00009216415,0.00009300969,0.0001129685,0.0001267969,0.0001291453,0.0002993094,0.0003775874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176474,"about_ca_system_score_gemma":0.0001920341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112944,"about_ca_topic_score_gemma":0.001285249,"domain_scores_codex":[0.9999546,0.000009765795,0.000003790398,0.000008891213,0.0000116474,0.00001121251],"domain_scores_gemma":[0.9999747,0.000003896716,0.000009978925,0.000002064957,0.000002585253,0.000006638799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002793335,0.0000626511,0.0001417081,0.0001015091,0.000007209876,0.0001375936,0.00001702295,0.0002669854,0.9909902,0.000234601,0.0001486597,0.007612545],"study_design_scores_gemma":[0.0001839278,0.002573161,0.002639023,0.00001065424,0.00002449898,0.0007635305,0.00002167598,0.001226868,0.9868329,0.00007077255,0.005641928,0.0000111733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819164,0.005980184,0.006379757,0.0002913022,0.00005960009,0.0001268735,0.0004464867,0.0001720259,0.004627525],"genre_scores_gemma":[0.9899948,0.002298567,0.003694598,0.00005789166,0.00001096091,0.00004761629,0.0002685557,0.000007345955,0.003619718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00116438,"threshold_uncertainty_score":0.003895223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566922243357745,"score_gpt":0.2539070943923958,"score_spread":0.2382378719588183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}