{"id":"W2026824776","doi":"10.1242/jcs.02580","title":"Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway","year":2005,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Biology; Jurkat cells; Programmed cell death; Cell biology; FADD; Apoptosis; Caspase 8; Nerve growth factor IB; Mitochondrion; Caspase; Cancer cell; Signal transduction; Inner mitochondrial membrane; Necroptosis; Mitochondrial permeability transition pore; Cancer; Transcription factor; Biochemistry; Nuclear receptor; Immunology; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001057395,0.0004100876,0.0002781026,0.0002313794,0.0001652435,0.000306765,0.0001699725,0.0002484271,0.001094716],"category_scores_gemma":[0.0001313013,0.0001006266,0.0003085739,0.0001503631,0.0002052069,0.0002459227,0.0002523123,0.0005331587,0.000420797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039646,"about_ca_system_score_gemma":0.0002938487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002693194,"about_ca_topic_score_gemma":0.0004844537,"domain_scores_codex":[0.9998023,0.00003003142,0.0000218283,0.00003010453,0.00006846304,0.00004738439],"domain_scores_gemma":[0.9999008,0.00001057224,0.00002917919,0.00001853504,0.00001900741,0.00002188966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006874962,0.00002409422,0.0002108171,0.00005747255,0.00001016703,0.0001664383,0.00001821611,0.00003676685,0.997846,0.0001722601,0.00003260611,0.001356445],"study_design_scores_gemma":[0.00001633368,0.0003350883,0.005720966,0.00000762353,0.00001982068,0.001699697,0.00004261563,0.0004037143,0.9889231,0.00005614458,0.002770605,0.000004294771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894305,0.003669664,0.003683954,0.00012365,0.00003321372,0.00004711841,0.000239126,0.00008190932,0.002690789],"genre_scores_gemma":[0.9939361,0.001656645,0.001146199,0.00004503366,0.000007729203,0.00003870219,0.0004432548,0.000008524345,0.00271788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001094716,"threshold_uncertainty_score":0.003662229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263749403783337,"score_gpt":0.2305435168420743,"score_spread":0.2179060228042409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}