{"id":"W2026827248","doi":"10.1002/1521-4141(200108)31:8<2382::aid-immu2382>3.0.co;2-k","title":"Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation","year":2001,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"","keywords":"SH3 domain; CTL*; Biology; Cell biology; MHC class I; Transfection; Mutant; SH2 domain; Major histocompatibility complex; Proto-oncogene tyrosine-protein kinase Src; Kinase; Immune system; CD8; Genetics; Cell culture; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000992495,0.0003021015,0.0002811192,0.00009779174,0.0001329258,0.0001920432,0.0002048205,0.0002309687,0.002041035],"category_scores_gemma":[0.00009058092,0.0001066414,0.0002248962,0.000107599,0.000257319,0.0001250197,0.0001636798,0.0006367554,0.0003964558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002955333,"about_ca_system_score_gemma":0.000225796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001412095,"about_ca_topic_score_gemma":0.001615966,"domain_scores_codex":[0.9998835,0.00001491262,0.00001085993,0.00001714976,0.00002595255,0.00004761053],"domain_scores_gemma":[0.9999241,0.00002364352,0.00001293805,0.0000124889,0.000006346983,0.00002054364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158538,0.0000366101,0.00005824148,0.00002972429,0.000005178566,0.00004181173,0.000007282327,0.00004992677,0.9988952,0.00007487166,0.00004354068,0.0006417842],"study_design_scores_gemma":[0.00002220714,0.0001209757,0.003088403,0.000003117056,0.000006191053,0.0002027236,0.000009729431,0.0008085981,0.9942333,0.00002815747,0.001473567,0.000003023898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958737,0.0009082301,0.0009647777,0.00006541433,0.00004565576,0.00002357941,0.0004569656,0.00004125008,0.001620327],"genre_scores_gemma":[0.9957803,0.000392163,0.000805346,0.00004095186,0.0000071579,0.00002725101,0.0006113646,0.00001533084,0.002320066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041035,"threshold_uncertainty_score":0.00682795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784245933914693,"score_gpt":0.2508188349460434,"score_spread":0.2329763756068965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}