{"id":"W2026874869","doi":"10.1038/aps.2011.60","title":"TRPM7 in cerebral ischemia and potential target for drug development in stroke","year":2011,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"Magnesium in Health and Disease","field":"Nursing","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"","keywords":"Excitotoxicity; Neuroprotection; Glutamate receptor; Neuroscience; Ischemia; Transient receptor potential channel; Cortical spreading depression; Stroke (engine); Medicine; Brain ischemia; TRPM7; In vivo; Programmed cell death; Hypothermia; NMDA receptor; Pharmacology; Receptor; Biology; Anesthesia; Internal medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008306399,0.000587177,0.001590249,0.0003418475,0.0001370542,0.00004226398,0.0005054196,0.0004707601,0.0009272665],"category_scores_gemma":[0.0002462024,0.0004929777,0.0002589897,0.0002455245,0.00009266082,0.0001414251,0.0002127402,0.0007634328,0.00002545528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608294,"about_ca_system_score_gemma":0.0006321179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003427183,"about_ca_topic_score_gemma":0.00002249855,"domain_scores_codex":[0.9962448,0.0004040622,0.001360671,0.0008891453,0.0001749405,0.0009263122],"domain_scores_gemma":[0.9982257,0.0005475986,0.0004892385,0.0002489215,0.00004448577,0.0004440019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001525576,0.001017643,0.000311342,0.03716174,0.0000467395,0.00007764712,0.0003506277,5.512447e-7,0.000043552,0.00001619375,0.0198976,0.9395508],"study_design_scores_gemma":[0.002213544,0.0001403397,0.0001697344,0.0006058976,0.0003553528,0.000009098901,0.00001942395,0.00002008482,0.00007172571,0.00005206516,0.9957876,0.0005551788],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006277352,0.9867197,0.000001753507,0.0003625917,0.001475673,0.003583848,0.0001828824,0.00008032954,0.001315891],"genre_scores_gemma":[0.05874426,0.9324393,0.004115553,0.001192699,0.0005200338,0.002047787,0.000356182,0.00009925303,0.0004849305],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.97589,"threshold_uncertainty_score":0.999986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0699191887771885,"score_gpt":0.3792544669122097,"score_spread":0.3093352781350212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}