{"id":"W2026927555","doi":"10.2174/1389557053175371","title":"Taxol Anticancer Activity and DNA Binding","year":2005,"lang":"en","type":"article","venue":"Mini-Reviews in Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Intercalation (chemistry); Chemistry; Helix (gastropod); Binding constant; Stereochemistry; In vitro; Base pair; Biophysics; Capillary electrophoresis; Binding site; Biochemistry; Biology; Chromatography; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033074,0.0002575296,0.0001917029,0.000249109,0.0001514338,0.0003423099,0.000250156,0.000366603,0.003376144],"category_scores_gemma":[0.0003770039,0.000126919,0.0001335692,0.0002579324,0.0002114117,0.0001894197,0.0001478197,0.0003502838,0.0006392268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004161613,"about_ca_system_score_gemma":0.000192084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195022,"about_ca_topic_score_gemma":0.001050775,"domain_scores_codex":[0.9997775,0.00003752534,0.000008892081,0.0000521379,0.00007868219,0.00004524245],"domain_scores_gemma":[0.99984,0.00006203495,0.0000426615,0.000007090051,0.00002739151,0.00002075573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001320954,0.00002504237,0.0006593315,0.0001209031,0.00001163342,0.00003680769,0.00001693226,0.0001787624,0.9935133,0.0002690197,0.00005885119,0.004977394],"study_design_scores_gemma":[0.000009378621,0.0002293575,0.005798683,0.00001089825,0.0000134626,0.0002322789,0.00002027261,0.0005617444,0.9887326,0.0001095883,0.004276345,0.000005316181],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9604754,0.02723624,0.004770872,0.0001815906,0.0000228149,0.00006212114,0.0004993503,0.00006174797,0.006689827],"genre_scores_gemma":[0.9883235,0.005144828,0.001435317,0.00009076719,0.00001206612,0.00003286285,0.0007150011,0.00001001607,0.004235769],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003376144,"threshold_uncertainty_score":0.01129436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327848252895512,"score_gpt":0.2808103437073496,"score_spread":0.2675318611783945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}