{"id":"W2026927555","doi":"10.2174/1389557053175371","title":"Taxol Anticancer Activity and DNA Binding","year":2005,"lang":"en","type":"article","venue":"Mini-Reviews in Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Intercalation (chemistry); Chemistry; Helix (gastropod); Binding constant; Stereochemistry; In vitro; Base pair; Biophysics; Capillary electrophoresis; Binding site; Biochemistry; Biology; Chromatography; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004246766,0.0002576196,0.000364553,0.00001877161,0.00005409664,0.00001390636,0.0002313802,0.0002295573,0.0002235212],"category_scores_gemma":[0.0002396008,0.0002322496,0.00007946788,0.0001064588,0.0002003335,0.000007722786,0.0001274294,0.0002567388,0.00001816742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004287823,"about_ca_system_score_gemma":0.00005491394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000520568,"about_ca_topic_score_gemma":0.00001050681,"domain_scores_codex":[0.9986174,0.00003133835,0.0003315905,0.0004966368,0.0001772072,0.0003458983],"domain_scores_gemma":[0.9992695,0.00001820898,0.0001324004,0.0003961136,0.00001809321,0.0001656325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003782885,0.00005520443,0.001692064,0.0002074511,0.00001278292,0.000007926853,0.00003300979,2.690956e-7,0.9390813,5.133051e-7,0.003376678,0.055495],"study_design_scores_gemma":[0.0005299243,0.00002789506,0.0007309753,0.0001824505,0.00002190369,0.00006354589,0.00005202691,0.00001867957,0.7556489,0.000003372591,0.2424944,0.0002260197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824221,0.009240391,0.00003037432,0.0005302158,0.00005844304,0.000135887,0.00000962888,0.00001119913,0.007561807],"genre_scores_gemma":[0.9900155,0.005995166,0.000651921,0.0003831662,0.0008642049,0.00004183181,0.00003135858,0.00002349268,0.001993327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2391177,"threshold_uncertainty_score":0.9470863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01327848252895512,"score_gpt":0.2808103437073496,"score_spread":0.2675318611783945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}