{"id":"W2026940625","doi":"10.1016/j.chembiol.2011.09.017","title":"Paenibacillus polymyxa PKB1 Produces Variants of Polymyxin B-Type Antibiotics","year":2011,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Paenibacillus polymyxa; Biology; Gene cluster; Polymyxin; Gene; Nonribosomal peptide; Microbiology; Peptide; Lantibiotics; Polymyxin B; Antibiotics; Paenibacillus; Biosynthesis; Biochemistry; Bacteria; Bacteriocin; Genetics; 16S ribosomal RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001844571,0.000290179,0.0003573729,0.00002771289,0.00005773619,0.000008421238,0.0005345549,0.000493718,0.0003245814],"category_scores_gemma":[0.0002620717,0.0002684263,0.0001160888,0.0001555917,0.000540981,0.000004920729,0.0002189113,0.000128602,0.00002091076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001423779,"about_ca_system_score_gemma":0.0001673861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003795062,"about_ca_topic_score_gemma":0.000004056375,"domain_scores_codex":[0.9983004,0.00005617902,0.0004520228,0.0006482925,0.0000868545,0.0004562857],"domain_scores_gemma":[0.9985638,0.00001338345,0.000282447,0.0008459018,0.0001811519,0.0001133339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002568305,0.0001386023,0.05367916,0.00008028479,0.0001030035,0.00000591797,0.0000523532,2.15765e-7,0.9445677,0.00008868412,0.0004323474,0.0005948705],"study_design_scores_gemma":[0.0003471262,0.0002376908,0.02005182,0.00002262862,0.00003254184,0.00004325311,0.00007186199,0.000002814703,0.9749393,0.0001379303,0.003822498,0.0002904726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888226,0.001024662,0.00015361,0.00003668711,0.0003912673,0.0001320847,0.00006334785,0.00002589198,0.009349865],"genre_scores_gemma":[0.9957095,0.0003069543,0.001691625,0.00007409303,0.0003279477,5.576902e-7,0.0002322191,0.00003578291,0.001621287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03362734,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017485188386103,"score_gpt":0.2468594776014239,"score_spread":0.2266846257175628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}