{"id":"W2026982091","doi":"10.1016/j.semcancer.2015.02.006","title":"Sustained proliferation in cancer: Mechanisms and novel therapeutic targets","year":2015,"lang":"en","type":"review","venue":"Seminars in Cancer Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":780,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; European Regional Development Fund; National Institutes of Health; Junta de Castilla y León; European Commission; Ministerio de Ciencia e Innovación; Ministero dell’Istruzione, dell’Università e della Ricerca; Ministero della Salute; Terry Fox Foundation; European Cooperation in Science and Technology; University of Glasgow; Consejería de Educación, Junta de Castilla y León; National Institute of Allergy and Infectious Diseases; Al Jalila Foundation; Ministry of Education, Culture, Sports, Science and Technology; United Arab Emirates University; Cancer Research UK; Purdue University; Avon Foundation for Women; Purdue University Center for Cancer Research; National Institute of Diabetes and Digestive and Kidney Diseases; Temple University; Federación Española de Enfermedades Raras; American Cancer Society; Università degli Studi Roma Tre; Center for Hierarchical Manufacturing, National Science Foundation; Breast Cancer Research Foundation; Associazione Italiana per la Ricerca sul Cancro; National Science Foundation","keywords":"Biology; Wnt signaling pathway; Cancer research; Protein kinase B; Cancer stem cell; Signal transduction; Stromal cell; Cell growth; Cancer cell; Cancer; Angiogenesis; Cell cycle; Cell biology; Stem cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000615339,0.0007391037,0.0009286197,0.0009018093,0.0003014369,0.001591912,0.0007737347,0.001215122,0.005388532],"category_scores_gemma":[0.0002465053,0.0002116897,0.0004657593,0.0007305277,0.0006725294,0.001204634,0.0006536567,0.002501302,0.002339841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001031983,"about_ca_system_score_gemma":0.0004578695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002814592,"about_ca_topic_score_gemma":0.0006873705,"domain_scores_codex":[0.9998247,0.00004086955,0.000008711144,0.00002998913,0.00004632778,0.00004943164],"domain_scores_gemma":[0.999889,0.00002750048,0.00002010152,0.000009665903,0.00002327077,0.00003036409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00114663,0.001146426,0.0006940213,0.00604482,0.0001415795,0.0009176409,0.0001746068,0.001689521,0.06769035,0.02273316,0.04829422,0.849327],"study_design_scores_gemma":[0.0008134826,0.002572891,0.004743541,0.001967898,0.0002259942,0.003251575,0.0002768594,0.002730472,0.03209402,0.02992279,0.9213297,0.00007082264],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009655609,0.9658203,0.0033939,0.009432873,0.0009056377,0.00009640854,0.0002834688,0.0002011823,0.01021065],"genre_scores_gemma":[0.07656907,0.9019272,0.004894964,0.003363041,0.001823454,0.0002529666,0.000642634,0.0000573932,0.01046922],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005388532,"threshold_uncertainty_score":0.01802641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0547250051787864,"score_gpt":0.3812292932929021,"score_spread":0.3265042881141156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}