{"id":"W2027007284","doi":"10.1016/j.bcp.2008.01.009","title":"Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter","year":2008,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Mutant; ATP hydrolysis; Nucleotide; Transmembrane domain; Biophysics; Biochemistry; ATPase; Chemistry; ATP-binding cassette transporter; Efflux; Transporter; Biology; Amino acid; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165133,0.0001312983,0.0003290651,0.0000921703,0.00008643877,0.000001209141,0.0001156863,0.00009310718,0.000170478],"category_scores_gemma":[0.00000955656,0.000079212,0.0001264655,0.0002508679,0.0004408883,0.00003601995,0.00002403143,0.0003548944,0.00000141302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003359569,"about_ca_system_score_gemma":0.0000699088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001891175,"about_ca_topic_score_gemma":0.000006093004,"domain_scores_codex":[0.9989454,0.0000412491,0.0004130592,0.0002004188,0.0001875924,0.0002123426],"domain_scores_gemma":[0.9995056,0.0001186574,0.0001271417,0.0001275431,0.00004785516,0.00007315421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003923524,0.00016787,0.03897924,0.00006698147,0.0001048017,0.00001166345,0.0004212492,0.000007828833,0.9591512,0.00006655673,0.0005763221,0.00005391933],"study_design_scores_gemma":[0.002045722,0.00004785728,0.2051742,0.00007180672,0.0002419715,0.00004913352,0.0001832168,0.00004582318,0.7906783,0.00007626314,0.001308583,0.00007713615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969997,0.0002889399,0.00007532702,0.001649232,0.000178539,0.0003828,0.00003580327,0.00001515433,0.0003745487],"genre_scores_gemma":[0.9991005,0.00008220726,0.0002168933,0.0001971682,0.0001988014,0.00002208583,0.00002761508,0.00001536502,0.0001393662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.168473,"threshold_uncertainty_score":0.3230172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808018360708039,"score_gpt":0.2685871473440151,"score_spread":0.2505069637369347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}