{"id":"W2027009452","doi":"10.1007/s00125-005-0045-y","title":"Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes","year":2005,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Prince Edward Island; Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"Canadian Institutes of Health Research; Banting and Best Diabetes Centre, University of Toronto; Novo Nordisk; Canadian Diabetes Association; American Diabetes Association","keywords":"Internal medicine; Endocrinology; Insulin; Insulin resistance; Insulin oscillation; Beta cell; Type 2 diabetes; Diabetes mellitus; Biology; Insulin tolerance test; Islet; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007872573,0.002501327,0.0008038369,0.002490683,0.0005058988,0.0009136996,0.001011617,0.001561809,0.002211077],"category_scores_gemma":[0.0004961785,0.001086609,0.0008460944,0.0009446573,0.001364656,0.0007970812,0.0005893776,0.003057984,0.0007179706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008327255,"about_ca_system_score_gemma":0.0003889569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005590043,"about_ca_topic_score_gemma":0.0007328714,"domain_scores_codex":[0.9991968,0.0002413719,0.00008859123,0.0001456762,0.0002046314,0.0001228398],"domain_scores_gemma":[0.9990095,0.0001641782,0.000348779,0.0001409788,0.00003157614,0.0003050026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002469139,0.0005989294,0.0006571492,0.00008027122,0.00004073068,0.0007493715,0.00005584266,0.0004805821,0.992609,0.0007648037,0.0002201529,0.001274058],"study_design_scores_gemma":[0.001525034,0.007236455,0.01528417,0.0001180216,0.0002917735,0.005685177,0.0001890503,0.00505955,0.9588264,0.001163537,0.004539488,0.00008137622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993587,0.001069389,0.002138378,0.0004239839,0.0001122388,0.00006630327,0.0007495336,0.000286324,0.001566736],"genre_scores_gemma":[0.9890498,0.00180165,0.003759406,0.0002335462,0.00008693889,0.0001591593,0.0009426487,0.0001996701,0.003767228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002501327,"threshold_uncertainty_score":0.007396758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01845671521508737,"score_gpt":0.243582008666882,"score_spread":0.2251252934517946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}