{"id":"W2027021865","doi":"10.1074/jbc.m206882200","title":"The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":472,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Flip; Activator (genetics); Cell biology; Caspase 8; Apoptosis; Caspase; Chemistry; Cancer research; Programmed cell death; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414024,0.0003784721,0.0002302557,0.0003677541,0.0003037795,0.0005095617,0.0002334985,0.0003978958,0.005657496],"category_scores_gemma":[0.0002807254,0.0001235043,0.0002002753,0.0002209432,0.0002910985,0.0005158337,0.000437369,0.0004985211,0.001966661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005391669,"about_ca_system_score_gemma":0.000343597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001619258,"about_ca_topic_score_gemma":0.0001837126,"domain_scores_codex":[0.9998839,0.00001523962,0.00001058619,0.00002676122,0.00003478492,0.00002869319],"domain_scores_gemma":[0.9998288,0.00001329701,0.00005904133,0.00001296243,0.00003342264,0.00005258356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003594686,0.00006989883,0.002114289,0.0002530126,0.00003701742,0.0009754317,0.00005432814,0.0002594913,0.9422239,0.003629315,0.001807767,0.04821602],"study_design_scores_gemma":[0.0001909069,0.001135941,0.01947827,0.0001137086,0.00008657006,0.01192624,0.000209567,0.001950735,0.8453655,0.004500766,0.1149861,0.00005575776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9259484,0.02518542,0.02175673,0.001435458,0.0004545397,0.0002081098,0.001920944,0.0005700955,0.02252035],"genre_scores_gemma":[0.9776372,0.003666163,0.003370357,0.0002939594,0.0001264236,0.00007973125,0.001517548,0.00002269979,0.01328582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005657496,"threshold_uncertainty_score":0.0189262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05999064173657175,"score_gpt":0.2679688171563063,"score_spread":0.2079781754197345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}