{"id":"W2027040596","doi":"10.1152/ajpgi.00092.2011","title":"Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Public Health Service","keywords":"Ursodeoxycholic acid; DNA damage; Apoptosis; Deoxycholic acid; Cancer research; Chemistry; Reactive oxygen species; NF-κB; Molecular biology; Bile acid; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001539743,0.0002513919,0.0002610855,0.0002623356,0.0001508591,0.0002107934,0.0001047021,0.0002132793,0.001121451],"category_scores_gemma":[0.0001398827,0.0001617465,0.0003119819,0.0002157946,0.0001536731,0.0001631863,0.0001588318,0.000368394,0.0002752815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518318,"about_ca_system_score_gemma":0.0001023843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004399844,"about_ca_topic_score_gemma":0.0005619663,"domain_scores_codex":[0.9998335,0.00003599867,0.00002627499,0.00002947603,0.00004294418,0.00003185332],"domain_scores_gemma":[0.9998933,0.00001503922,0.0000231611,0.00002192786,0.0000199561,0.00002664281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000227574,0.0000340008,0.0007581675,0.00006139939,0.00000829325,0.000092045,0.00002908564,0.00001104243,0.9976234,0.00001633344,0.00001743494,0.001121146],"study_design_scores_gemma":[0.00004968066,0.001110298,0.03165771,0.00001518371,0.00004098755,0.001223413,0.0001214002,0.0004429336,0.9621091,0.0000737939,0.003149732,0.00000578752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906009,0.006731387,0.001385177,0.00008476501,0.00003518701,0.00002372952,0.0002117904,0.00003377931,0.0008931704],"genre_scores_gemma":[0.9949928,0.002381765,0.001025794,0.00005000137,0.00001337421,0.00002907251,0.0003711223,0.000006887273,0.00112922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121451,"threshold_uncertainty_score":0.003751636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888537333686513,"score_gpt":0.2718005907692272,"score_spread":0.2429152174323621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}