{"id":"W2027040596","doi":"10.1152/ajpgi.00092.2011","title":"Deoxycholic acid causes DNA damage while inducing apoptotic resistance through NF-κB activation in benign Barrett's epithelial cells","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; U.S. Public Health Service","keywords":"Ursodeoxycholic acid; DNA damage; Apoptosis; Deoxycholic acid; Cancer research; Chemistry; Reactive oxygen species; NF-κB; Molecular biology; Bile acid; Biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001953755,0.0003015484,0.0008210692,0.0002075347,0.0001022435,0.000009094458,0.0001983692,0.00005185216,0.0001468016],"category_scores_gemma":[0.0001207113,0.0002323273,0.0001453816,0.0003173245,0.0008689198,0.0002798038,0.00008738843,0.0007085936,0.00001442318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401853,"about_ca_system_score_gemma":0.0002236325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005474175,"about_ca_topic_score_gemma":0.00004641455,"domain_scores_codex":[0.9979464,0.000339609,0.0005115822,0.0004244729,0.0002064093,0.0005715546],"domain_scores_gemma":[0.9984921,0.0002218362,0.0005513245,0.0002558412,0.0002326989,0.0002461695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003926781,0.0004373717,0.003519451,0.00007732886,0.000109762,0.0001657919,0.001259884,0.00001021121,0.9892647,0.0001856423,0.00009166988,0.0009513763],"study_design_scores_gemma":[0.002132748,0.008527935,0.7543299,0.0004610094,0.00008435863,0.0004298648,0.0009629065,0.0000181977,0.2310616,0.001772029,0.00002605478,0.0001933776],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988631,0.0003521892,0.0001181561,0.0001945182,0.00006610002,0.0002097222,0.00001197006,0.00001585356,0.0001683656],"genre_scores_gemma":[0.9911502,0.0001589807,0.007941134,0.0003938478,0.000271252,0.00001335692,0.00001078605,0.00002630629,0.00003415373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7582031,"threshold_uncertainty_score":0.9474031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888537333686513,"score_gpt":0.2718005907692272,"score_spread":0.2429152174323621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}