{"id":"W2027069545","doi":"10.1186/1471-2180-13-98","title":"Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters","year":2013,"lang":"en","type":"article","venue":"BMC Microbiology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Gene duplication; Homology (biology); Transmembrane protein; ATP-binding cassette transporter; Monophyly; Sequence alignment; Genetics; SUPERFAMILY; Protein family; Computational biology; Integral membrane protein; Protein superfamily; Sequence (biology); Sequence homology; Membrane topology; Membrane protein; Phylogenetics; Evolutionary biology; Gene; Transmembrane domain; Transporter; Peptide sequence; Receptor; Membrane; Clade","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680326,0.0001225219,0.0003083698,0.0001446027,0.00006548154,0.000003831554,0.00007746089,0.0001785932,0.000528959],"category_scores_gemma":[0.0001096172,0.0001030339,0.0001088885,0.0001255236,0.0001391062,0.00006989554,0.00004256545,0.0002254672,0.0004779836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003658453,"about_ca_system_score_gemma":0.00008772845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006355164,"about_ca_topic_score_gemma":0.00001513905,"domain_scores_codex":[0.9990362,0.00008620536,0.0003749155,0.0002225826,0.00004006401,0.0002400135],"domain_scores_gemma":[0.9993193,0.00009876392,0.0001364417,0.0002709867,0.00009180905,0.00008270768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003627688,0.00006777233,0.1668162,0.00005271747,0.0000433992,0.000002997047,0.0002610138,0.000003261502,0.815957,0.0003270528,0.01595886,0.0004734462],"study_design_scores_gemma":[0.001313126,0.0000835797,0.9056937,0.00005789888,0.00009459237,0.0006562239,0.0002565459,0.00003465266,0.00308924,0.00007673798,0.08850966,0.0001340672],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965162,0.0005254696,0.0001585538,0.0007735991,0.0004435201,0.0003247496,0.00003297903,0.00004166948,0.001183203],"genre_scores_gemma":[0.992066,0.00001830711,0.003907626,0.0003999539,0.0002237169,0.00001938713,0.0002340824,0.00001642675,0.00311445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8128677,"threshold_uncertainty_score":0.6143672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03647226152371567,"score_gpt":0.2506678664112966,"score_spread":0.214195604887581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}