{"id":"W2027071019","doi":"10.1016/j.tiv.2009.11.011","title":"Syk is a novel target of arsenic trioxide (ATO) and is involved in the toxic effect of ATO in human neutrophils","year":2009,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Syk; Piceatannol; Phagocytosis; Arsenic trioxide; Chemistry; Degranulation; Kinase; Cell biology; Phosphorylation; Cancer research; Apoptosis; Signal transduction; Biology; Tyrosine kinase; Biochemistry; Receptor; Resveratrol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001440428,0.0003778961,0.000301526,0.0002713183,0.000415068,0.0003539543,0.0002015386,0.0004360895,0.001621797],"category_scores_gemma":[0.0001294181,0.0001420375,0.0003482193,0.000205493,0.0003033925,0.0003005026,0.0002875625,0.0005335723,0.000483312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061348,"about_ca_system_score_gemma":0.0002854801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431672,"about_ca_topic_score_gemma":0.0005069582,"domain_scores_codex":[0.9998755,0.00001765599,0.00000705924,0.00002610441,0.00004154283,0.00003203098],"domain_scores_gemma":[0.9999179,0.00001385409,0.00002575973,0.000006989753,0.00001489054,0.00002069335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002840437,0.00002421936,0.0009594877,0.00007615906,0.00001529921,0.0002839741,0.00001989856,0.00006530352,0.9960373,0.0002230997,0.0001015267,0.001909753],"study_design_scores_gemma":[0.00003346649,0.0004896622,0.02799598,0.00001295736,0.00006691137,0.002683593,0.0001190149,0.001201993,0.9620897,0.0004687323,0.004826393,0.0000116861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865654,0.006177437,0.004195954,0.0003424175,0.00007571634,0.00003463308,0.0004180209,0.0000471978,0.002143127],"genre_scores_gemma":[0.993276,0.001809529,0.001615915,0.00008019702,0.00003566682,0.00002281812,0.000656313,0.000006465375,0.002497046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001621797,"threshold_uncertainty_score":0.005425394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454868147062255,"score_gpt":0.264547513585153,"score_spread":0.2499988321145305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}