{"id":"W2027114238","doi":"10.1002/jlcr.862","title":"Synthesis of <sup>14</sup>C‐labelled EM‐800 (SCH 57050) and EM‐652·HCl (SCH 57068·HCl, acolbifene), pure selective estrogen receptor modulators","year":2004,"lang":"en","type":"article","venue":"Journal of Labelled Compounds and Radiopharmaceuticals","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Diastereomer; Racemization; Yield (engineering); Radiosynthesis; Amine gas treating; Racemic mixture; Moiety; Hydrochloride; Resolution (logic); Nuclear chemistry; Salt (chemistry); Resorcinol; Enantiomeric excess; Stereochemistry; Medicinal chemistry; Enantiomer; Organic chemistry; Enantioselective synthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000882479,0.0005255966,0.001029858,0.0002432564,0.0003112727,0.00009441849,0.0003748377,0.0005940578,0.00002788544],"category_scores_gemma":[0.000225302,0.0004163032,0.000359928,0.0003768944,0.0003287229,0.00003957673,0.0001888018,0.000756093,0.000005965751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008090233,"about_ca_system_score_gemma":0.0002890956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006151424,"about_ca_topic_score_gemma":9.046235e-7,"domain_scores_codex":[0.9970046,0.0003516041,0.001013561,0.0005266092,0.0004975213,0.0006060558],"domain_scores_gemma":[0.9978414,0.0001958887,0.0005770146,0.0003166225,0.0004358715,0.0006332311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002216596,0.001349623,0.001899063,0.0002153638,0.002690981,0.0001063762,0.0007076028,0.001253415,0.9833881,0.000277733,0.001391486,0.004503673],"study_design_scores_gemma":[0.01576644,0.002441913,0.0003781572,0.0003675996,0.001157484,0.001224163,0.0005771168,0.00112175,0.9697556,0.0005081737,0.005890062,0.000811519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719288,0.02649963,0.0001149974,0.0005366778,0.0002313276,0.0004403272,0.00003602776,0.00001727756,0.0001948755],"genre_scores_gemma":[0.9858553,0.01107819,0.002234599,0.0002001968,0.000416067,0.00001498049,0.00001219625,0.00007253532,0.0001159371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01542144,"threshold_uncertainty_score":0.9998289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008107747999508358,"score_gpt":0.2633749445459596,"score_spread":0.2552671965464512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}