{"id":"W2027121987","doi":"10.1186/1758-2652-12-25","title":"Five‐year follow up of genotypic resistance patterns in HIV‐1 subtype C infected patients in Botswana after failure of thymidine analogue‐based regimens","year":2009,"lang":"en","type":"article","venue":"Journal of the International AIDS Society","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Stavudine; Didanosine; Lamivudine; Medicine; Zidovudine; Genotype; Internal medicine; Reverse-transcriptase inhibitor; Resistance mutation; Regimen; Nevirapine; Reverse transcriptase; Virology; Gastroenterology; Human immunodeficiency virus (HIV); Viral load; Biology; Virus; Genetics; Antiretroviral therapy; Viral disease; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003960089,0.0002518506,0.0002648864,0.0008189295,0.0008569272,0.0005166041,0.0003649406,0.0005416514,0.0008425918],"category_scores_gemma":[0.001499416,0.0002601475,0.0002904586,0.0007615181,0.0002999282,0.0003285329,0.0003340575,0.0005229154,0.0001985066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001126954,"about_ca_system_score_gemma":0.000534632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03526415,"about_ca_topic_score_gemma":0.04098652,"domain_scores_codex":[0.9997625,0.00004409536,0.00001967802,0.00004535085,0.00003624658,0.00009220664],"domain_scores_gemma":[0.9992812,0.00009386786,0.000293218,0.00004165544,0.0001343157,0.0001556824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00013031,0.00002748139,0.9977723,0.000003431692,0.00001993068,0.0003233778,0.0002082018,0.00004146137,0.0004268534,0.000004956097,0.00005369487,0.0009880804],"study_design_scores_gemma":[0.00001026104,0.0001595204,0.9987645,0.000005771533,0.0000150521,0.0003793361,0.0003725271,0.0001157281,0.00006505122,0.000005112276,0.0001028725,0.000004285923],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997558,0.00003618651,0.00001108007,0.00001450565,0.000001653777,0.00000339767,0.00009493041,0.000001009007,0.0000814951],"genre_scores_gemma":[0.9996605,0.00002182614,0.00002042728,0.00002137411,0.000001480427,0.000003924884,0.0001857464,5.701387e-7,0.0000843034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03526415,"threshold_uncertainty_score":0.07011783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007193319229568291,"score_gpt":0.2340876107533002,"score_spread":0.2268942915237319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}