{"id":"W2027130956","doi":"10.1016/j.bbrc.2012.05.065","title":"Preferential binding of IFI16 protein to cruciform structure and superhelical DNA","year":2012,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Akademie Věd České Republiky; Grantová Agentura České Republiky","keywords":"HMG-box; Replication protein A; Molecular biology; DNA supercoil; Biology; DNA binding site; DNA; Protein–DNA interaction; Retinoblastoma-like protein 1; E2F1; Promoter; DNA-binding protein; Electrophoretic mobility shift assay; Transcription factor; Cell biology; DNA replication; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003589994,0.0002992749,0.0003536988,0.0002635178,0.0004394144,0.0003230568,0.0003565254,0.0004525677,0.004046424],"category_scores_gemma":[0.0006026025,0.0002953497,0.0004180179,0.0001537429,0.0002883174,0.0002527796,0.0004224253,0.0004624764,0.0007682391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000478962,"about_ca_system_score_gemma":0.0003600272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001338622,"about_ca_topic_score_gemma":0.001870029,"domain_scores_codex":[0.9996905,0.00005346866,0.00001609575,0.00008376257,0.00006368827,0.00009250528],"domain_scores_gemma":[0.9996104,0.00009009606,0.00004553927,0.00006603416,0.00005662143,0.0001314604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001267943,0.000008469116,0.0003522258,0.00003240988,0.000004507782,0.00003385544,0.00002051829,0.00002815921,0.9987882,0.00009370601,0.00005351356,0.0004576489],"study_design_scores_gemma":[0.00001143567,0.0001022165,0.007290971,0.000007597199,0.000004491933,0.0001918881,0.00004394819,0.0003885165,0.9902766,0.00006075838,0.001615908,0.00000568487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943302,0.001338885,0.002272216,0.00008931086,0.00004446249,0.00001917289,0.0001350183,0.00005388151,0.001716907],"genre_scores_gemma":[0.9949891,0.0002716352,0.001636919,0.00007486242,0.00001006447,0.0000204905,0.0004001167,0.00002371619,0.002573102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004046424,"threshold_uncertainty_score":0.01353657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07177522962265545,"score_gpt":0.3721649488963034,"score_spread":0.300389719273648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}