{"id":"W2027138344","doi":"10.1089/108076803762718105","title":"Hydrolysis of Bimatoprost (Lumigan) to its Free Acid by Ocular Tissue <i>In Vitro</i>","year":2003,"lang":"en","type":"article","venue":"Journal of Ocular Pharmacology and Therapeutics","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Bimatoprost; Ciliary body; Sclera; Cornea; Chemistry; Agonist; Prodrug; Hydrolysis; Receptor; In vitro; Pharmacology; Ophthalmology; Biochemistry; Ocular hypertension; Medicine; Intraocular pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002144885,0.0003290187,0.0007273532,0.0004043852,0.0001923662,0.00001789954,0.0004184099,0.0006015052,0.0003350314],"category_scores_gemma":[0.00008367174,0.0003159179,0.0001817205,0.0005565354,0.0001840086,0.0002269951,0.00007278121,0.001435518,0.00002216797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008942413,"about_ca_system_score_gemma":0.0001340549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000728004,"about_ca_topic_score_gemma":0.000005060253,"domain_scores_codex":[0.9967518,0.00122681,0.0009306766,0.0002898741,0.0002803539,0.0005204279],"domain_scores_gemma":[0.9984534,0.0002349746,0.0005403006,0.000193355,0.0002545214,0.0003234179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009700305,0.0006660837,0.001426142,0.0000804392,0.0006658109,0.000129847,0.0008437615,0.000222607,0.9857956,0.0002464192,0.0005371918,0.008416045],"study_design_scores_gemma":[0.003312679,0.0003875487,0.00009855384,0.00001663125,0.0004443408,0.0002433033,0.00008139657,0.0002935524,0.7808617,0.0006596069,0.2133695,0.0002311829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843158,0.01015421,0.0008052294,0.001782133,0.001561985,0.0006046463,0.00006778068,0.00001870296,0.0006895034],"genre_scores_gemma":[0.9912729,0.002559918,0.0005749391,0.005235603,0.0001382556,0.00002392912,0.00000414846,0.00003601659,0.0001542637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2128323,"threshold_uncertainty_score":0.9999293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04990556788287313,"score_gpt":0.3827400223956901,"score_spread":0.332834454512817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}