{"id":"W2027151716","doi":"10.1016/j.vaccine.2011.07.090","title":"A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors","year":2011,"lang":"en","type":"article","venue":"Vaccine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"HPV vaccines; Genotype; Cervical cancer; Medicine; Vaccination; Immunity; Immunology; Cancer; HPV infection; Virology; Immune system; Oncology; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001562125,0.0004248135,0.0003895972,0.0002474567,0.0001447493,0.0003111621,0.0002583306,0.0005089656,0.001343024],"category_scores_gemma":[0.0001072884,0.0001661177,0.0002143354,0.0001146807,0.0003166116,0.0003290526,0.0002474937,0.0009694443,0.0004030502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002216179,"about_ca_system_score_gemma":0.0003393324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002721969,"about_ca_topic_score_gemma":0.0006561567,"domain_scores_codex":[0.9998885,0.00001300456,0.000004301874,0.00002506598,0.00003121328,0.00003787352],"domain_scores_gemma":[0.9999542,0.00000729703,0.000008198225,0.000008013716,0.000005294197,0.00001703959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003968069,0.00064203,0.0002804526,0.00007185953,0.00001565857,0.0001644423,0.00002816831,0.0006646257,0.9730611,0.0006199871,0.0005330218,0.02352179],"study_design_scores_gemma":[0.000890026,0.01183421,0.004468495,0.00003443357,0.0001453611,0.003900309,0.00008908131,0.005672471,0.9528511,0.0007475864,0.01934085,0.00002607798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781091,0.003368868,0.01265496,0.0004970694,0.000162366,0.0001379298,0.0002014116,0.0002698817,0.004598329],"genre_scores_gemma":[0.9901287,0.001272809,0.00518339,0.0001972015,0.00004321799,0.00006304742,0.0003583235,0.00001845883,0.002734763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001343024,"threshold_uncertainty_score":0.004492819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265411127626345,"score_gpt":0.2360598946819015,"score_spread":0.213405783405638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}