{"id":"W2027151716","doi":"10.1016/j.vaccine.2011.07.090","title":"A novel, broad spectrum therapeutic HPV vaccine targeting the E7 proteins of HPV16, 18, 31, 45 and 52 that elicits potent E7-specific CD8T cell immunity and regression of large, established, E7-expressing TC-1 tumors","year":2011,"lang":"en","type":"article","venue":"Vaccine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"HPV vaccines; Genotype; Cervical cancer; Medicine; Vaccination; Immunity; Immunology; Cancer; HPV infection; Virology; Immune system; Oncology; Biology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009710906,0.0004982002,0.0008491926,0.000286971,0.0005804597,0.00004051091,0.0005335489,0.0003143443,0.0006387805],"category_scores_gemma":[0.0000970067,0.000315508,0.0001579515,0.0003529138,0.0001324052,0.0003162649,0.0003836448,0.0007107535,0.000009444136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003240859,"about_ca_system_score_gemma":0.00007947617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006103402,"about_ca_topic_score_gemma":0.00002506164,"domain_scores_codex":[0.9972829,0.0006125282,0.0008390293,0.0004795597,0.0001123504,0.0006736454],"domain_scores_gemma":[0.9978218,0.0003408807,0.000811814,0.0008395589,0.0001454321,0.00004048016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003906045,0.0006544456,0.005110244,0.0001389412,0.0002155721,0.000004457956,0.002976782,0.000001443142,0.9804859,0.00008965138,0.0007302608,0.005686229],"study_design_scores_gemma":[0.005109002,0.0007466315,0.1233135,0.0003709519,0.00008534556,0.0001335048,0.002097146,0.000011292,0.8605927,0.0001261396,0.007077328,0.0003363755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8964722,0.1011361,0.0005533862,0.000226198,0.0002789902,0.0008248649,0.00004296362,0.0000551719,0.0004101081],"genre_scores_gemma":[0.993103,0.005146122,0.0003863045,0.0001112203,0.00003599233,0.00003047158,0.000046298,0.00005873932,0.001081866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1198932,"threshold_uncertainty_score":0.9999297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265411127626345,"score_gpt":0.2360598946819015,"score_spread":0.213405783405638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}