{"id":"W2027154313","doi":"10.1097/fjc.0b013e3181f50a70","title":"Redox Regulation of Myocardial Erk 1/2 Phosphorylation in Experimental Hyperthyroidism: Role of Thioredoxin-Peroxiredoxin System","year":2010,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University","funders":"","keywords":"Peroxiredoxin; Kinase; Thioredoxin; MAPK/ERK pathway; Internal medicine; Endocrinology; Glutathione peroxidase; Glutathione; Antioxidant; Extracellular; Chemistry; Oxidative stress; p38 mitogen-activated protein kinases; Medicine; Peroxidase; Biochemistry; Enzyme; Superoxide dismutase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090234,0.0001831018,0.0006640767,0.0001806651,0.00003699675,0.000004188414,0.0002750967,0.0003528366,0.00002284647],"category_scores_gemma":[0.00006468717,0.0001663856,0.0007451845,0.0001516038,0.0002394355,0.00001938379,0.00007724293,0.0003127515,0.000001159477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003272422,"about_ca_system_score_gemma":0.0001419587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002070848,"about_ca_topic_score_gemma":0.000003423908,"domain_scores_codex":[0.9980647,0.0004360396,0.0007640041,0.0002390958,0.0002874732,0.0002086704],"domain_scores_gemma":[0.9987183,0.00003253606,0.0005520605,0.000288229,0.0003327195,0.00007611078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007691042,0.0001330236,0.002693324,0.0000268044,0.001183409,0.00001371992,0.0001381583,0.00201141,0.9909086,0.0001254378,0.0001676996,0.001829333],"study_design_scores_gemma":[0.002426301,0.000469533,0.016306,0.00002114134,0.0002377606,0.0002286179,0.0004103943,0.0001212902,0.9749162,0.00002692414,0.004698467,0.0001373584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836766,0.01382834,0.0003327411,0.00001867256,0.00117233,0.0002219721,0.00001145836,0.000003907043,0.0007339917],"genre_scores_gemma":[0.9982938,0.0003684969,0.0006385125,0.00001565322,0.000622576,0.000009884279,0.00002044272,0.00001928727,0.00001138821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01599236,"threshold_uncertainty_score":0.678501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004350127280581234,"score_gpt":0.2393597640666946,"score_spread":0.2350096367861134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}