{"id":"W2027194833","doi":"10.5402/2012/736860","title":"Downregulation in GATA4 and Downstream Structural and Contractile Genes in the db/db Mouse Heart","year":2012,"lang":"en","type":"article","venue":"ISRN Endocrinology","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôtel-Dieu de Montréal","funders":"Canadian Institutes of Health Research; Midwestern University; Heart and Stroke Foundation of Canada; Charles and Helen Schwab Foundation; Diabetes Action Research and Education Foundation","keywords":"Downregulation and upregulation; Downstream (manufacturing); GATA4; Gene; Cell biology; Biology; Internal medicine; Genetics; Gene expression; Medicine; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002860351,0.0007933745,0.0004868493,0.001029931,0.000298142,0.0005806288,0.0003731353,0.0005953455,0.002594064],"category_scores_gemma":[0.0001485811,0.0005500031,0.000478638,0.0003098921,0.0005067537,0.0003102962,0.0003065086,0.001259544,0.0007464763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003121607,"about_ca_system_score_gemma":0.0002504586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007737546,"about_ca_topic_score_gemma":0.001005125,"domain_scores_codex":[0.9996421,0.00003319628,0.00005397974,0.000123426,0.00007174317,0.00007556653],"domain_scores_gemma":[0.9996035,0.00002751854,0.0001251263,0.00003321118,0.00003161306,0.0001791065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002045634,0.0000432335,0.0003413392,0.00002214121,0.000006682086,0.00005155208,0.000010626,0.00001221199,0.9989717,0.00004611092,0.00001680022,0.0002730019],"study_design_scores_gemma":[0.0001274105,0.0009964621,0.05470948,0.00002809724,0.0001127135,0.001570277,0.0001531721,0.0006966102,0.9394707,0.0001757752,0.001940922,0.00001835801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936947,0.001450765,0.00228545,0.0001547719,0.00004891679,0.00002137418,0.001239531,0.0001534249,0.0009511139],"genre_scores_gemma":[0.98326,0.001715371,0.003894604,0.0003503431,0.00004294512,0.0001682439,0.00216917,0.0001977937,0.008201579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594064,"threshold_uncertainty_score":0.008677959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01345536495242858,"score_gpt":0.2959819540163148,"score_spread":0.2825265890638862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}