{"id":"W2027208874","doi":"10.4161/chan.4.1.10260","title":"Impaired stretch modulation in potentially lethal cardiac sodium channel mutants","year":2010,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Sodium channel; Mutant; Modulation (music); Cell biology; Chemistry; Biophysics; Sodium; Biology; Biochemistry; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002225032,0.0001854719,0.0004167919,0.0001591515,0.00007046336,0.00001344899,0.00006610977,0.0002774446,0.000123786],"category_scores_gemma":[0.00008138594,0.0001745733,0.0002066557,0.0002268378,0.00007838782,0.0001022194,0.0000404215,0.0005349313,0.00008437481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003736081,"about_ca_system_score_gemma":0.00009858897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005966608,"about_ca_topic_score_gemma":0.00001367571,"domain_scores_codex":[0.9987571,0.00005248107,0.0002325819,0.0003474201,0.0001789627,0.0004314312],"domain_scores_gemma":[0.9993715,0.00003425925,0.00006140141,0.0003152872,0.00008370543,0.0001338947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006746749,0.0002245588,0.003612027,0.00007405524,0.0001669278,0.0008721472,0.001379831,0.0004488856,0.9732115,0.000274323,0.0007254668,0.0183356],"study_design_scores_gemma":[0.007483465,0.001164573,0.6925803,0.000225484,0.0002705046,0.001058316,0.0004840165,0.02845851,0.2587824,0.007235765,0.0009559653,0.001300743],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955875,0.0000943468,0.00006015359,0.000936066,0.002231821,0.0004081884,0.00001552952,0.00008132953,0.0005850935],"genre_scores_gemma":[0.9974898,0.00002615678,0.00007832572,0.000150732,0.00173659,0.00003679727,0.00008415926,0.00002954535,0.0003679607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7144291,"threshold_uncertainty_score":0.7118893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183597171218969,"score_gpt":0.2533701167394469,"score_spread":0.2415341450272572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}