{"id":"W2027208874","doi":"10.4161/chan.4.1.10260","title":"Impaired stretch modulation in potentially lethal cardiac sodium channel mutants","year":2010,"lang":"en","type":"article","venue":"Channels","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Sodium channel; Mutant; Modulation (music); Cell biology; Chemistry; Biophysics; Sodium; Biology; Biochemistry; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009153728,0.0003336651,0.0001792926,0.00009140775,0.0000797949,0.0001675163,0.0002483418,0.0002883809,0.001276726],"category_scores_gemma":[0.0001844688,0.0001106478,0.0002704934,0.0000727219,0.0001899851,0.0001731078,0.000228724,0.0003301213,0.0003673167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174029,"about_ca_system_score_gemma":0.00009623722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003905199,"about_ca_topic_score_gemma":0.0004079945,"domain_scores_codex":[0.9998993,0.00001370649,0.00002170386,0.00002438957,0.00002486023,0.00001600282],"domain_scores_gemma":[0.9998166,0.00002823276,0.0000780547,0.00001995358,0.00001092295,0.00004615894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003572422,0.000006341128,0.00009199433,0.000007703537,0.000002580549,0.00007282461,0.000008150747,0.00002973934,0.9994639,0.00002227463,0.000005578171,0.0002532559],"study_design_scores_gemma":[0.00005175529,0.000687296,0.02652347,0.00001436107,0.00002559772,0.002123222,0.00006210303,0.002711169,0.9665383,0.0001144234,0.00113144,0.00001684763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988661,0.0001551425,0.0005870288,0.00001848596,0.000008105205,0.000006324349,0.0001143251,0.00003066622,0.0002138426],"genre_scores_gemma":[0.9985827,0.0001339522,0.0004730047,0.00001950746,0.00000383279,0.00001423932,0.0001615193,0.00002564817,0.0005857337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001276726,"threshold_uncertainty_score":0.00427109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183597171218969,"score_gpt":0.2533701167394469,"score_spread":0.2415341450272572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}