{"id":"W2027212453","doi":"10.1016/j.molbiopara.2011.08.006","title":"IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice","year":2011,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Guangdong Academy of Sciences","keywords":"Biology; Leishmania donovani; Amastigote; Purine metabolism; Hypoxanthine-guanine phosphoribosyltransferase; Biochemistry; Guanine; De novo synthesis; Purine; Nucleotide; Xanthine; Leishmania; Molecular biology; Gene; Genetics; Enzyme; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001826803,0.0002759391,0.0003183594,0.000227726,0.00003874808,0.00001618691,0.0002010331,0.0005120925,0.000006546708],"category_scores_gemma":[0.0002776443,0.0002747288,0.0001025354,0.0003686347,0.0002599428,0.000009281258,0.0001916098,0.0002808083,0.000003228224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000379776,"about_ca_system_score_gemma":0.00009719271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532608,"about_ca_topic_score_gemma":0.0004922376,"domain_scores_codex":[0.9979349,0.0001114725,0.0003955023,0.0008263523,0.0001311037,0.0006006229],"domain_scores_gemma":[0.9994718,0.00002920789,0.0000715363,0.0002085329,0.00009216443,0.000126727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007545637,0.0003806688,0.06464837,0.00007463479,0.00002073891,0.00007452154,0.00008305595,0.000001170199,0.9334605,0.0002617112,0.00005703025,0.0001830335],"study_design_scores_gemma":[0.001593584,0.0003744705,0.03091999,0.00002547996,0.000016497,0.00004477184,0.00001813202,0.00008000078,0.9656724,0.0008975101,0.00004597472,0.0003112082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968069,0.001137851,0.001056679,0.0001470709,0.0000505728,0.0005883106,0.00002243035,0.00001054817,0.0001796194],"genre_scores_gemma":[0.9984331,0.0001741221,0.0007462675,0.0003196012,0.00003944771,0.0001635173,0.00008622909,0.00002746815,0.00001031508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03372839,"threshold_uncertainty_score":0.9999705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669534480825484,"score_gpt":0.2877509317455054,"score_spread":0.2710555869372505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}