{"id":"W2027212453","doi":"10.1016/j.molbiopara.2011.08.006","title":"IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice","year":2011,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Guangdong Academy of Sciences","keywords":"Biology; Leishmania donovani; Amastigote; Purine metabolism; Hypoxanthine-guanine phosphoribosyltransferase; Biochemistry; Guanine; De novo synthesis; Purine; Nucleotide; Xanthine; Leishmania; Molecular biology; Gene; Genetics; Enzyme; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964642,0.001205349,0.0004356046,0.001440455,0.0003370245,0.0006700433,0.0007236283,0.0008221368,0.002596337],"category_scores_gemma":[0.0002862189,0.000765619,0.000536485,0.0004339675,0.001239945,0.0004816795,0.0006506159,0.002063404,0.0007681011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000721861,"about_ca_system_score_gemma":0.0004025307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102939,"about_ca_topic_score_gemma":0.001499944,"domain_scores_codex":[0.999606,0.00007954623,0.00004554358,0.0000821439,0.00007960163,0.0001072041],"domain_scores_gemma":[0.9992778,0.0001145555,0.000243646,0.00008223589,0.00003466014,0.0002471675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005865957,0.00009319898,0.0002744668,0.00007536501,0.00001503877,0.0003920001,0.00002774473,0.00006356624,0.9970722,0.0004518021,0.00008721135,0.0008608137],"study_design_scores_gemma":[0.000124531,0.000409177,0.005423638,0.00002228556,0.00006383931,0.001962228,0.00009673522,0.0007285448,0.9885148,0.0002383628,0.002397245,0.00001856256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906031,0.001507504,0.003348898,0.0003994977,0.00008306855,0.00004938966,0.001657973,0.0003467262,0.002003796],"genre_scores_gemma":[0.9931002,0.0006525265,0.001273508,0.00008117908,0.00001729692,0.00006348709,0.001115641,0.0001021896,0.00359403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002596337,"threshold_uncertainty_score":0.008685648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669534480825484,"score_gpt":0.2877509317455054,"score_spread":0.2710555869372505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}