{"id":"W2027214837","doi":"10.1074/jbc.m500501200","title":"Insulin Regulates the Membrane Arrival, Fusion, and C-terminal Unmasking of Glucose Transporter-4 via Distinct Phosphoinositides","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"State University of New York","keywords":"Wortmannin; Phosphatidylinositol; GLUT4; Glucose transporter; Immunoelectron microscopy; Cell biology; Epitope; Biology; Glucose uptake; Phosphoinositide 3-kinase; Biochemistry; Kinase; Molecular biology; Insulin; Chemistry; Protein kinase B; Signal transduction; Endocrinology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003130839,0.0001544689,0.0002487515,0.0000125927,0.00006611471,0.00001106514,0.0002018225,0.00020577,0.00009266239],"category_scores_gemma":[0.00003912318,0.00009302244,0.0001850435,0.00005318094,0.0002171559,0.000006343344,0.00002775152,0.0001835622,3.486178e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008605813,"about_ca_system_score_gemma":0.00002985249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003323378,"about_ca_topic_score_gemma":0.0000030979,"domain_scores_codex":[0.9990033,0.00002813397,0.000503698,0.0001713509,0.0001389451,0.000154606],"domain_scores_gemma":[0.9993083,0.00002740245,0.0003202159,0.0001518655,0.0001017848,0.00009047065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003671632,0.00008297329,0.006657661,0.00004037068,0.00004142881,0.00002088566,0.00005396913,0.00001744718,0.9892347,0.000001897471,0.000009980885,0.003471554],"study_design_scores_gemma":[0.0005390443,0.0002145856,0.02064028,0.00004839223,0.00004644888,0.0003927964,0.00005753795,0.0000405302,0.973427,0.0000584908,0.004412819,0.0001220537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944663,0.004046337,0.001085981,0.000216092,0.00003475227,0.00005106848,0.00001089198,0.000003673891,0.00008491444],"genre_scores_gemma":[0.9975151,0.001508282,0.0003570426,0.00005500784,0.0003738605,0.000001187269,0.0001449866,0.000007955222,0.00003662314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01580765,"threshold_uncertainty_score":0.3793345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009454450669361894,"score_gpt":0.2160671527756183,"score_spread":0.2066127021062564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}